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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Stomach


High impact information on Stomach


Chemical compound and disease context of Stomach


Biological context of Stomach


Anatomical context of Stomach

  • Rat stomachs were perfused in situ with Krebs-Ringer bicarbonate buffer containing 10% ovine erythrocytes and gassed with 95% O2-5% CO2 [21].
  • To determine whether local hormones may mediate CRF-induced acid inhibition, we examined the peptide's effect on the release of somatostatin and gastrin from cultured canine gastric D and G cells and from isolated perfused rat stomachs [22].
  • PCFS was seen around the glands of intestinal metaplastic mucosa in both Cdx2 transgenic mouse and human stomachs [23].
  • METHODS: The stomachs of IP(-/-) or their wild-type counterparts (IP(+/+)), anaesthetised with urethane (1.225 g/kg), were doubly cannulated from the oesophageal and duodenal sides, and the gastric mucosa was perfused (1 ml/min) with physiological saline [24].
  • These morphological data correlated with total immunoreactive TRH content extracted from the whole stomachs of six fetuses and two preterm infants [25].

Associations of Stomach with chemical compounds

  • The morphology of ligated rat stomachs filled with absolute ethanol for 1, 7, 15, 30, and 60 min was studied [26].
  • Bioassays of plasma extracts were performed in anesthetized rats with perfused stomachs and acid out-puts were compared with those produced by normal saline and by 50 ng pentagastrin given in random order [27].
  • We have quantitatively evaluated in semithin sections the amount and depth of gastric mucosal damage to rat stomachs exposed to absolute ethanol with and without prostaglandin (16,16-dimethyl PGE2) pretreatment [28].
  • Chambered stomachs were damaged by hypertonic saline followed by either acidic or neutral isotonic saline [29].
  • METHODS: The passage of intragastrically administered Evans blue in the small bowel of unanesthetized rats was followed, and the stomachs were weighted after killing the rats [30].

Gene context of Stomach

  • Immunocytochemical, histological, and ultrastructural analyses of Atp4a(-/-) stomachs revealed the presence of chief cells, demonstrating that the lack of acid secretion does not interfere with their differentiation [31].
  • Other prostaglandins (thromboxane B2, PGD2, PGF(2alpha), and 6-keto-PGF(1alpha)) were significantly elevated in stomachs of mPGES-1-null mice but not in other tissues [32].
  • Activin has a positive growth effect on gonadal tumor cells in culture and directly causes the cancer cachexia-like syndrome in inhibin-deficient mice via interaction with activin receptor type IIA in livers and stomachs [33].
  • These results demonstrate that two HMFG glycoproteins implicated in prevention of infection, MUC-1 mucin and lactadherin, survive and maintain their integrity in the stomachs of human milk-fed preterm infants [34].
  • The present study examines the role of endogenous ANP in regulating endocrine secretion in rat and human stomachs [35].

Analytical, diagnostic and therapeutic context of Stomach


  1. Induction of intestinal metaplasia in the stomachs of rats by N-methyl-N'-nitro-N-nitrosoguanidine. Matsukura, N., Kawachi, T., Sasajima, K., Sano, T., Sugimura, T., Hirota, T. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. Hirose, H., Takeuchi, K., Okabe, S. Gastroenterology (1991) [Pubmed]
  3. Gastrin cell distribution in normal human stomachs and in patients with Zollinger-Ellison syndrome. Voillemot, N., Potet, F., Mary, J.Y., Lewin, M.J. Gastroenterology (1978) [Pubmed]
  4. Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(-/-) mice. Berg, D.J., Lynch, N.A., Lynch, R.G., Lauricella, D.M. Am. J. Pathol. (1998) [Pubmed]
  5. Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice. Mohammadi, M., Czinn, S., Redline, R., Nedrud, J. J. Immunol. (1996) [Pubmed]
  6. Protective role of intracellular superoxide dismutase against extracellular oxidants in cultured rat gastric cells. Hiraishi, H., Terano, A., Sugimoto, T., Harada, T., Razandi, M., Ivey, K.J. J. Clin. Invest. (1994) [Pubmed]
  7. Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N'-nitro-N-nitrosoguanidine. Tatematsu, M., Furihata, C., Katsuyama, T., Mera, Y., Inoue, T., Matsushima, T., Ito, N. J. Natl. Cancer Inst. (1987) [Pubmed]
  8. Formation of a transplacental mutagen, 1,3-Di(4-sulfamoylphenyl)triazene, from sodium nitrite and sulfanilamide in human gastric juice and in the stomachs of hamsters. Endo, H., Noda, H., Kinoshita, N., Inui, N., Nishi, Y. J. Natl. Cancer Inst. (1980) [Pubmed]
  9. Formation of methylnitrosocyanamide from methylguanidine and sodium nitrite in simulated gastric juice and in stomachs of rats: quantitative estimation by a mutagenicity assay. Ishizawa, M., Utsunomiya, T., Kinoshita, N., Endo, H. J. Natl. Cancer Inst. (1979) [Pubmed]
  10. Changes in pepsinogen isozymes in stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine. Furihata, C., Sasajima, K., Kazama, S., Kogure, K., Kawachi, T. J. Natl. Cancer Inst. (1975) [Pubmed]
  11. Levels of nitrite, nitrate, N-nitroso compounds, ascorbic acid and total bile acids in gastric juice of patients with and without precancerous conditions of the stomach. Sobala, G.M., Pignatelli, B., Schorah, C.J., Bartsch, H., Sanderson, M., Dixon, M.F., Shires, S., King, R.F., Axon, A.T. Carcinogenesis (1991) [Pubmed]
  12. Fluctuation of fetal rat hepatic histidine decarboxylase activity through the glucocorticoid-ACTH system. Ohmori, E., Imanishi, N., Ohgoh, M., Fukui, T., Ichikawa, A. Biochem. Pharmacol. (1991) [Pubmed]
  13. Cell proliferation and cell loss in intramucosal signet ring cell carcinoma of canine stomachs induced by N-ethyl-N'-nitro-N-nitrosoguanidine. Sugihara, H., Tsuchihashi, Y., Hattori, T., Fukuda, M., Fujita, S. J. Cancer Res. Clin. Oncol. (1985) [Pubmed]
  14. Lower esophageal sphincter integrity is maintained during succinylcholine-induced fasciculations in dogs with "full" stomachs. Cook, W.P., Schultetus, R.R. Anesth. Analg. (1990) [Pubmed]
  15. Role of interleukin-4 in down-regulation of endothelin-1 during gastric ulcer healing: effect of sucralfate. Slomiany, B.L., Piotrowski, J., Slomiany, A. J. Physiol. Pharmacol. (2000) [Pubmed]
  16. Nitric oxide enhances resistance of SCID mice to mucosal candidiasis. Vazquez-Torres, A., Jones-Carson, J., Warner, T., Balish, E. J. Infect. Dis. (1995) [Pubmed]
  17. Interferon gamma induction of gastric mucous neck cell hypertrophy. Kang, W., Rathinavelu, S., Samuelson, L.C., Merchant, J.L. Lab. Invest. (2005) [Pubmed]
  18. The vascular and glandular organoprotective properties of metronidazole in the rodent stomach. Ko, J.K., Ching, C.K., Chow, J.Y., Zhang, S.T., Lam, S.K., Cho, C.H. Aliment. Pharmacol. Ther. (1997) [Pubmed]
  19. Methylation of liver DNA of rat and mouse by N-nitrosodimethylamine formed in vivo from dimethylamine and nitrite. Meier-Bratschi, A., Lutz, W.K., Schlatter, C. Food Chem. Toxicol. (1983) [Pubmed]
  20. Effect of 16,16-dimethyl prostaglandin-E2 given intra-arterially or intra-gastrically, on acid secretion by canine stomachs perfused ex vivo. Kowalewski, K., Kolodej, A. Prostaglandins (1978) [Pubmed]
  21. Effect of antibodies to somatostatin on acid secretion and gastrin release by the isolated perfused rat stomach. Short, G.M., Doyle, J.W., Wolfe, M.M. Gastroenterology (1985) [Pubmed]
  22. Peripheral acid inhibitory action of corticotropin releasing factor: mediation by nongastric mechanisms. Todisco, A., Park, J., Lezoche, E., Debas, H., Tache, Y., Yamada, T. Gastroenterology (1987) [Pubmed]
  23. Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma. Mutoh, H., Sakurai, S., Satoh, K., Osawa, H., Tomiyama, T., Kita, H., Yoshida, T., Tamada, K., Yamamoto, H., Isoda, N., Ido, K., Sugano, K. Gut (2005) [Pubmed]
  24. Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide. Arai, K., Ohno, T., Saeki, T., Mizuguchi, S., Kamata, K., Hayashi, I., Saigenji, K., Murata, T., Narumiya, S., Majima, M. Gut (2003) [Pubmed]
  25. Gastrin (G) cells are the cellular site of the gastric thyrotropin-releasing hormone in human fetuses and newborns. A chromatographic, radioimmunological, and immunocytochemical study. Grasso, S., Buffa, R., Martino, E., Bartalena, L., Curzio, M., Salomone, E. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  26. Morphology of rat gastric mucosal damage, defense, and restitution in the presence of luminal ethanol. Ito, S., Lacy, E.R. Gastroenterology (1985) [Pubmed]
  27. Detection of a circulating gastric secretagogue in plasma extracts from normogastrinemic patients with acid hypersecretion. Bugat, R., Walsh, J.H., Ippoliti, A., Elashoff, J., Grossman, M.I. Gastroenterology (1976) [Pubmed]
  28. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Lacy, E.R., Ito, S. Gastroenterology (1982) [Pubmed]
  29. Role of sensory afferent neurons in hypertonic damage and restitution of the rat gastric mucosa. Grønbech, J.E., Lacy, E.R. Gastroenterology (1996) [Pubmed]
  30. Inhibition of intestinal motility and reversal of postlaparotomy ileus by selective alpha 2-adrenergic drugs in the rat. Tanila, H., Kauppila, T., Taira, T. Gastroenterology (1993) [Pubmed]
  31. Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. Spicer, Z., Miller, M.L., Andringa, A., Riddle, T.M., Duffy, J.J., Doetschman, T., Shull, G.E. J. Biol. Chem. (2000) [Pubmed]
  32. Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile. Boulet, L., Ouellet, M., Bateman, K.P., Ethier, D., Percival, M.D., Riendeau, D., Mancini, J.A., Méthot, N. J. Biol. Chem. (2004) [Pubmed]
  33. Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice. Cipriano, S.C., Chen, L., Kumar, T.R., Matzuk, M.M. Endocrinology (2000) [Pubmed]
  34. Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants. Peterson, J.A., Hamosh, M., Scallan, C.D., Ceriani, R.L., Henderson, T.R., Mehta, N.R., Armand, M., Hamosh, P. Pediatr. Res. (1998) [Pubmed]
  35. Gastric atrial natriuretic peptide regulates endocrine secretion in antrum and fundus of human and rat stomach. Gower, W.R., Premaratne, S., McCuen, R.W., Arimura, A., McAfee, Q., Schubert, M.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  36. Androgen biosynthesis in the stomach: expression of cytochrome P450 17 alpha-hydroxylase/17,20-lyase messenger ribonucleic acid and protein, and metabolism of pregnenolone and progesterone by parietal cells of the rat gastric mucosa. Le Goascogne, C., Sananès, N., Eychenne, B., Gouézou, M., Baulieu, E.E., Robel, P. Endocrinology (1995) [Pubmed]
  37. Cyclooxygenase isozymes involved in adaptive functional responses in rat stomach after barrier disruption. Takeeda, M., Yamato, M., Kato, S., Takeuchi, K. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  38. Effect of taurine on ulcerogenic response and impaired ulcer healing induced by monochloramine in rat stomachs. Kato, S., Umeda, M., Takeeda, M., Kanatsu, K., Takeuchi, K. Aliment. Pharmacol. Ther. (2002) [Pubmed]
  39. Acid-induced gastric damage in rats is aggravated by starvation and prevented by several nutrients. Hung, C.R., Neu, S.L. J. Nutr. (1997) [Pubmed]
  40. The effect of total parenteral nutrition (TPN) on gastrin release in the rat. Campos, R.V., Wheeler, M.B., Pederson, R.A., Buchan, A.M., Brown, J.C. Regul. Pept. (1987) [Pubmed]
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