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Gene Review:

fhlA - formate hydrogenlyase transcriptional...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2726, JW2701, fhl

Maupin, J.A. et al., Schlensog, V. et al., Brøndsted, L. et al., Korsa, I. et al., Brøndsted, L. et al.

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Disease relevance of fhlA

Genetic regulation of formate hydrogenlyase of Escherichia coli: role of the fhlA gene product as a transcriptional activator for a new regulatory gene, fhlB [1].

High impact information on fhlA

The nucleotide sequence of the fhlA gene was determined and it was shown to code for a protein with a calculated Mr of 78,467 [2].
Characterization of fhlA mutations resulting in ligand-independent transcriptional activation and ATP hydrolysis [3].
The formate induction was independent of the fhlA gene product [4].
Formate induction was not mediated by the fhlA gene product, and nitrate repression was not mediated by the narL gene product [5].
The concentration of formate required for maximum expression of the fhlB gene was about 15 mM; this value decreased to about 3 mM in the presence of plasmid pSE-133, which carries the fhlA gene in a multicopy plasmid [1].

References

Genetic regulation of formate hydrogenlyase of Escherichia coli: role of the fhlA gene product as a transcriptional activator for a new regulatory gene, fhlB. Maupin, J.A., Shanmugam, K.T. J. Bacteriol. (1990) [Pubmed]
Identification and sequence analysis of the gene encoding the transcriptional activator of the formate hydrogenlyase system of Escherichia coli. Schlensog, V., Böck, A. Mol. Microbiol. (1990) [Pubmed]
Characterization of fhlA mutations resulting in ligand-independent transcriptional activation and ATP hydrolysis. Korsa, I., Böck, A. J. Bacteriol. (1997) [Pubmed]
Effect of growth conditions on expression of the acid phosphatase (cyx-appA) operon and the appY gene, which encodes a transcriptional activator of Escherichia coli. Brøndsted, L., Atlung, T. J. Bacteriol. (1996) [Pubmed]
Anaerobic regulation of the hydrogenase 1 (hya) operon of Escherichia coli. Brøndsted, L., Atlung, T. J. Bacteriol. (1994) [Pubmed]

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