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Gene Review

lysS  -  lysine tRNA synthetase, constitutive

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2885, JW2858, asuD, herC
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Disease relevance of lysS


High impact information on lysS

  • Thus, we refer to the two genes as the prfB-herC operon [2].
  • This downstream open reading frame was identified as herC, a gene defined by a suppressor mutation that restores replication of a ColE1 plasmid mutant [2].
  • These antisuppressor mutations asuD, asuE, and asuF map at 61.9, 25.3, and 76.3 min, respectively, on the E. coli chromosome [3].
  • The 1832 bp E. coli DNA fragment, containing the wild-type allele of the herC mutation, was cloned and an open reading frame for the HerC protein was determined [4].
  • The herC mutation is recessive to its wild-type allele and supports maintenance of the mutant replicon in the absence of RNase H. The herC mutation alone conferred cold-sensitive growth, suggesting that the herC gene product is essential for cell growth [4].


  1. Homology of aspartyl- and lysyl-tRNA synthetases. Gampel, A., Tzagoloff, A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. Chromosomal location and structure of the operon encoding peptide-chain-release factor 2 of Escherichia coli. Kawakami, K., Jönsson, Y.H., Björk, G.R., Ikeda, H., Nakamura, Y. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. Antisuppressor mutation in Escherichia coli defective in biosynthesis of 5-methylaminomethyl-2-thiouridine. Sullivan, M.A., Cannon, J.F., Webb, F.H., Bock, R.M. J. Bacteriol. (1985) [Pubmed]
  4. Isolation and characterization of herC, a mutation of Escherichia coli affecting maintenance of ColE1. Kawakami, K., Naito, S., Inoue, N., Nakamura, Y., Ikeda, H., Uchida, H. Mol. Gen. Genet. (1989) [Pubmed]
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