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Gene Review

nudF  -  ADP-ribose pyrophosphatase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3025, JW3002, adpP, aspP, rdsA, ...
 
 
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Disease relevance of nudF

 

High impact information on nudF

  • Comparison with other members of the subfamily revealed a conserved proline 16 amino acid residues downstream of the Nudix box, common to all of the ADP-ribose pyrophosphatase subfamily [4].
  • By contrast, Slr1690 showed very low activity for ADP-ribose and had four substitutions of amino acids in the Nudix motif, indicating that Slr1690 is not an active ADP-ribose pyrophosphatase [2].

References

  1. The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Gabelli, S.B., Bianchet, M.A., Bessman, M.J., Amzel, L.M. Nat. Struct. Biol. (2001) [Pubmed]
  2. Systematic characterization of the ADP-ribose pyrophosphatase family in the Cyanobacterium Synechocystis sp. strain PCC 6803. Okuda, K., Hayashi, H., Nishiyama, Y. J. Bacteriol. (2005) [Pubmed]
  3. Overproduction, crystallization and preliminary diffraction data of ADP-ribose pyrophosphatase from Thermus thermophilus HB8. Yoshiba, S., Nakagawa, N., Masui, R., Shibata, T., Inoue, Y., Yokoyama, S., Kuramitsu, S. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
  4. Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. Dunn, C.A., O'Handley, S.F., Frick, D.N., Bessman, M.J. J. Biol. Chem. (1999) [Pubmed]
 
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