Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

folB - dihydroneopterin aldolase and...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3048, JW3030, ygiG

Haussmann, C. et al., Goyer, A. et al.

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Disease relevance of folB

The folX and folB gene products were both expressed to high yield in recombinant E. coli strains, and the recombinant proteins were purified to homogeneity [1].
The open reading frame ygiG of Hemophilus influenzae specifies a protein with the catalytic properties of an aldolase [1].

High impact information on folB

This enzyme catalyzes conversion of 7,8-dihydroneopterin (DHN) to 6-hydroxymethyl-7,8-dihydropterin, and is encoded by the folB gene in Escherichia coli [2].

References

Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase. Haussmann, C., Rohdich, F., Schmidt, E., Bacher, A., Richter, G. J. Biol. Chem. (1998) [Pubmed]
Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases. Goyer, A., Illarionova, V., Roje, S., Fischer, M., Bacher, A., Hanson, A.D. Plant Physiol. (2004) [Pubmed]

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