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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

CHEBI:17001     2-amino-6-[(1R,2R)-1,2,3- trihydroxypropyl]...

Synonyms: FT-0633495, AC1L22J7, C04874, 37343_FLUKA, 37343_SIGMA, ...
 
 
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Disease relevance of Dihydroneopterin

 

Psychiatry related information on Dihydroneopterin

 

High impact information on Dihydroneopterin

 

Chemical compound and disease context of Dihydroneopterin

 

Biological context of Dihydroneopterin

 

Anatomical context of Dihydroneopterin

 

Associations of Dihydroneopterin with other chemical compounds

 

Gene context of Dihydroneopterin

 

Analytical, diagnostic and therapeutic context of Dihydroneopterin

References

  1. Active site topology and reaction mechanism of GTP cyclohydrolase I. Nar, H., Huber, R., Auerbach, G., Fischer, M., Hösl, C., Ritz, H., Bracher, A., Meining, W., Eberhardt, S., Bacher, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus. Hennig, M., D'Arcy, A., Hampele, I.C., Page, M.G., Oefner, C., Dale, G.E. Nat. Struct. Biol. (1998) [Pubmed]
  3. Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro. Baier-Bitterlich, G., Baier, G., Fuchs, D., Böck, G., Hausen, A., Utermann, G., Pavelka, M., Wachter, H. Oncogene (1996) [Pubmed]
  4. Crystal structure of the bifunctional dihydroneopterin aldolase/6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Streptococcus pneumoniae. Garçon, A., Levy, C., Derrick, J.P. J. Mol. Biol. (2006) [Pubmed]
  5. Urinary neopterin concentrations vs total neopterins for clinical utility. Fuchs, D., Milstien, S., Krämer, A., Reibnegger, G., Werner, E.R., Goedert, J.J., Kaufman, S., Wachter, H. Clin. Chem. (1989) [Pubmed]
  6. Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Basset, G., Quinlivan, E.P., Ziemak, M.J., Diaz De La Garza, R., Fischer, M., Schiffmann, S., Bacher, A., Gregory, J.F., Hanson, A.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis. Nar, H., Huber, R., Heizmann, C.W., Thöny, B., Bürgisser, D. EMBO J. (1994) [Pubmed]
  8. Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase. Haussmann, C., Rohdich, F., Schmidt, E., Bacher, A., Richter, G. J. Biol. Chem. (1998) [Pubmed]
  9. A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase. Wang, Y., Scherperel, G., Roberts, K.D., Jones, A.D., Reid, G.E., Yan, H. J. Am. Chem. Soc. (2006) [Pubmed]
  10. Neopterin derivatives modulate toxicity of reactive species on Escherichia coli. Wede, I., Widner, B., Fuchs, D. Free Radic. Res. (1999) [Pubmed]
  11. Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations. Smith, G.K., Nichol, C.A. Arch. Biochem. Biophys. (1983) [Pubmed]
  12. Single amino acid substitutions disrupt tetramer formation in the dihydroneopterin aldolase enzyme of Pneumocystis carinii. Thomas, M.C., Ballantine, S.P., Bethell, S.S., Bains, S., Kellam, P., Delves, C.J. Biochemistry (1998) [Pubmed]
  13. Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection. Baier-Bitterlich, G., Fuchs, D., Wachter, H. Biochem. Pharmacol. (1997) [Pubmed]
  14. 7,8-Dihydroneopterin-induced apoptosis in Jurkat T lymphocytes: a comparison with anti-Fas- and hydrogen peroxide-mediated cell death. Wirleitner, B., Baier-Bitterlich, G., Böck, G., Widner, B., Fuchs, D. Biochem. Pharmacol. (1998) [Pubmed]
  15. Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase. Leitner, K.L., Meyer, M., Leimbacher, W., Peterbauer, A., Hofer, S., Heufler, C., Müller, A., Heller, R., Werner, E.R., Thöny, B., Werner-Felmayer, G. Biochem. J. (2003) [Pubmed]
  16. Neopterin and 7,8-dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2. Schobersberger, W., Hoffmann, G., Hobisch-Hagen, P., Bock, G., Volkl, H., Baier-Bitterlich, G., Wirleitner, B., Wachter, H., Fuchs, D. FEBS Lett. (1996) [Pubmed]
  17. Reduced pteridine derivatives induce apoptosis in PC12 cells. Enzinger, C., Wirleitner, B., Spöttl, N., Böck, G., Fuchs, D., Baier-Bitterlich, G. Neurochem. Int. (2002) [Pubmed]
  18. Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells. Schobersberger, W., Hoffmann, G., Grote, J., Wachter, H., Fuchs, D. FEBS Lett. (1995) [Pubmed]
  19. Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins. Wiederrecht, G.J., Brown, G.M. J. Biol. Chem. (1984) [Pubmed]
  20. Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class. Bauer, S., Schott, A.K., Illarionova, V., Bacher, A., Huber, R., Fischer, M. J. Mol. Biol. (2004) [Pubmed]
  21. Enzymic characterization of Bacillus subtilis GTP cyclohydrolase I. Evidence for a chemical dephosphorylation of dihydroneopterin triphosphate. De Saizieu, A., Vankan, P., van Loon, A.P. Biochem. J. (1995) [Pubmed]
  22. Two domains with amino-acid sequence similarity are required for dihydroneopterin aldolase function in the multifunctional folic acid synthesis Fas protein of Pneumocystis carinii. Volpe, F., Ballantine, S.P., Delves, C.J. Gene (1995) [Pubmed]
  23. Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases. Goyer, A., Illarionova, V., Roje, S., Fischer, M., Bacher, A., Hanson, A.D. Plant Physiol. (2004) [Pubmed]
  24. Cloning and developmental expression of zebrafish GTP cyclohydrolase I. Pelletier, I., Bally-Cuif, L., Ziegler, I. Mech. Dev. (2001) [Pubmed]
  25. Critical role of interleukin-1beta for transcriptional regulation of endothelial 6-pyruvoyltetrahydropterin synthase. Franscini, N., Blau, N., Walter, R.B., Schaffner, A., Schoedon, G. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  26. Effect of neopterin and 7,8-dihydroneopterin on tumor necrosis factor-alpha induced programmed cell death. Baier-Bitterlich, G., Fuchs, D., Murr, C., Reibnegger, G., Werner-Felmayer, G., Sgonc, R., Böck, G., Dierich, M.P., Wachter, H. FEBS Lett. (1995) [Pubmed]
  27. Purification of guanosine triphosphate cyclohydrolase I from Escherichia coli. The use of competitive inhibitors versus substrate as ligands in affinity chromatography. Ferre, J., Yim, J.J., Jacobson, K.B. J. Chromatogr. (1986) [Pubmed]
  28. Spin trapping study of antioxidant properties of neopterin and 7,8-dihydroneopterin. Oettl, K., Dikalov, S., Freisleben, H.J., Mlekusch, W., Reibnegger, G. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  29. Increase of GTP cyclohydrolase I activity in mononuclear blood cells by stimulation: detection of heterozygotes of GTP cyclohydrolase I deficiency. Blau, N., Joller, P., Atarés, M., Cardesa-Garcia, J., Niederwieser, A. Clin. Chim. Acta (1985) [Pubmed]
  30. Induction of apoptosis by 7,8-dihydroneopterin: involvement of radical formation. Wirleitner, B., Czaputa, R., Oettl, K., Böck, G., Widner, B., Reibnegger, G., Baier, G., Fuchs, D., Baier-Bitterlich, G. Immunobiology (2001) [Pubmed]
 
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