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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

obgE  -  GTPase involved in cell partioning and DNA...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3172, JW3150, cgtA, obg, yhbZ
 
 
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Disease relevance of obgE

  • Double cross-over experiments showed that the obgE gene is essential for growth in E. coli [1].
 

High impact information on obgE

  • Synergistic genetic interactions with recA and recB suggested that chromosome breaks and regressed forks accumulate in obgE mutants [2].
  • From characterization of the obgE temperature-sensitive mutant, we found that DNA replication was not inhibited, that the nucleoids did not partition and instead remained in the middle of cell, and that the cells elongated [1].
 

Analytical, diagnostic and therapeutic context of obgE

  • Mutants in obgE also exhibited asynchronous overreplication during normal growth, as revealed by flow cytometry [2].

References

  1. Deficiency of essential GTP-binding protein ObgE in Escherichia coli inhibits chromosome partition. Kobayashi, G., Moriya, S., Wada, C. Mol. Microbiol. (2001) [Pubmed]
  2. A bacterial G protein-mediated response to replication arrest. Foti, J.J., Schienda, J., Sutera, V.A., Lovett, S.T. Mol. Cell (2005) [Pubmed]
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