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Gene Review

mreD  -  cell wall structural complex MreBCD...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3237, JW3218
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Disease relevance of mreD


High impact information on mreD

  • The B. subtilis mreB, mreC, and mreD genes are the site of a conditional mutation (rodB1) that causes the production of aberrantly shaped cells under restrictive conditions [2].
  • Based on the sequence, it is suggested that the three mre genes (encoding the murein pathway), mreB, mreC and mreD, and these two ORFs possibly form an operon [1].
  • The initiation codon of the mreD gene overlaps the termination codon of the mreC gene by one nucleotide residue [3].

Biological context of mreD

  • New shape-determining genes in the mre cluster at 71 min on the Escherichia coli chromosome map, named mreC and mreD, were identified by complementation experiments using delta mre-678 mutant cells, which have a 5-kilobase-pair deletion encompassing the mre region, and by DNA sequencing [3].


  1. Sequence of the downstream flanking region of the shape-determining genes mreBCD of Escherichia coli. Wachi, M., Doi, M., Ueda, T., Ueki, M., Tsuritani, K., Nagai, K., Matsuhashi, M. Gene (1991) [Pubmed]
  2. Identification of Bacillus subtilis genes for septum placement and shape determination. Levin, P.A., Margolis, P.S., Setlow, P., Losick, R., Sun, D. J. Bacteriol. (1992) [Pubmed]
  3. New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells. Wachi, M., Doi, M., Okada, Y., Matsuhashi, M. J. Bacteriol. (1989) [Pubmed]
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