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Gene Review:

lptA - lipopolysaccharide export ABC transporter...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3189, JW3167, yhbN

Sperandeo, P. et al., Sperandeo, P. et al.

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Disease relevance of lptA

Here, we present evidence that two Escherichia coli essential genes, yhbN and yhbG, now renamed lptA and lptB, respectively, participate in LPS biogenesis [1].

High impact information on lptA

Complementation analysis of these mutants indicates that the locus is organized in at least three operons and that the three distal genes (yrbK, yhbN and yhbG) are essential for E. coli viability [2].

References

Characterization of lptA and lptB, Two Essential Genes Implicated in Lipopolysaccharide Transport to the Outer Membrane of Escherichia coli. Sperandeo, P., Cescutti, R., Villa, R., Di Benedetto, C., Candia, D., Deh??, G., Polissi, A. J. Bacteriol. (2007) [Pubmed]
Non-essential KDO biosynthesis and new essential cell envelope biogenesis genes in the Escherichia coli yrbG-yhbG locus. Sperandeo, P., Pozzi, C., Dehò, G., Polissi, A. Res. Microbiol. (2006) [Pubmed]

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