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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

acpT  -  4'-phosphopantetheinyl transferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3459, JW3440, yhhU
 
 
 
 
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Disease relevance of acpT

  • We report genetic and biochemical evidence that AcpT modifies two carrier proteins encoded in O-island 138, a cluster of fatty acid biosynthesis-like genes located adjacent to acpT in the genome of the pathogenic E. coli strain O157:H7 (E. coli K-12 and several other sequenced E. coli and Shigella strains lack O-island 138) [1].
 

High impact information on acpT

  • We demonstrate that AcpT cannot functionally replace AcpS in E. coli K-12 either in its native chromosomal location or upon insertion of acpT into the acpS chromosomal location [1].
  • Three PPTases have been previously been identified in Escherichia coli K-12 and other E. coli strains by homology searches and are encoded by the genes acpS, entD and acpT [1].

References

  1. A genome rearrangement has orphaned the Escherichia coli K-12 AcpT phosphopantetheinyl transferase from its cognate Escherichia coli O157:H7 substrates. De Lay, N.R., Cronan, J.E. Mol. Microbiol. (2006) [Pubmed]
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