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Gene Review:

adeD - cryptic adenine deaminase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3656, JW3640, ade, adeC, adu, ...

Petersen, C. et al., Shimaoka, M. et al.

Petersen, Møller, Valentin-Hansen,

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Disease relevance of ade

The cryptic adenine deaminase gene of Escherichia coli. Silencing by the nucleoid-associated DNA-binding protein, H-NS, and activation by insertion elements [1].

High impact information on ade

Gene fusion analysis indicated that ade transcription is repressed more than 10-fold by H-NS and that a region of 231 bp including the ade promoter is sufficient for this regulation [1].
The activating insertion elements essentially eliminated the H-NS-mediated silencing, and stimulated ade gene expression 2-3-fold independently of the H-NS protein [1].
Furthermore, to improve effective utilization of adenine, the yicP (adenine deaminase gene)-disrupted mutant was evaluated [2].
It showed higher inosine accumulation, of 3.7 g/l, than that of 2.8 g/l in the yicP wild strain when 4 g/l of yeast extract was added to the medium [2].

References

The cryptic adenine deaminase gene of Escherichia coli. Silencing by the nucleoid-associated DNA-binding protein, H-NS, and activation by insertion elements. Petersen, C., Møller, L.B., Valentin-Hansen, P. J. Biol. Chem. (2002) [Pubmed]
Effects of edd and pgi disruptions on inosine accumulation in Escherichia coli. Shimaoka, M., Kawasaki, H., Takenaka, Y., Kurahashi, O., Matsui, H. Biosci. Biotechnol. Biochem. (2005) [Pubmed]

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