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Gene Review:

pstC - phosphate ABC transporter permease

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3720, JW3705, phoW

Cox, G.B. et al., Surin, B.P. et al., Daigle, F. et al.

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Disease relevance of pstC

The pstC gene encodes an integral membrane protein of the phosphate-specific transport (Pst) system of Escherichia coli [1].

High impact information on pstC

We have produced an avirulent and serum-sensitive mutant of wild-type pathogenic strain 5131 O115:K"V165":F165 and have localized and identified the TnphoA insertion in the pstC gene of the pst-phoU operon [2].
Three mutant alleles of the pstC gene and one mutant allele of the pstB gene were produced by site-directed mutagenesis [1].
The amino acid substitutions resulting from the pstC gene mutations, Arg-237----Gln, Glu-240----Gln, or a combination of both, caused the loss of phosphate transport through the Pst system, but the alkaline phosphatase activity remained repressed [1].
The pstC, pstB, and phoU gene products were identified as peripheral membrane proteins [3].
Genetic complementation shows that of the four open reading frames in the new sequence, three correspond to known mutant alleles; the fourth, which was designated pstC, has not been described before and could not be related to any known mutant allele [3].

References

Specific amino acid residues in both the PstB and PstC proteins are required for phosphate transport by the Escherichia coli Pst system. Cox, G.B., Webb, D., Rosenberg, H. J. Bacteriol. (1989) [Pubmed]
Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs. Daigle, F., Fairbrother, J.M., Harel, J. Infect. Immun. (1995) [Pubmed]
Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships. Surin, B.P., Rosenberg, H., Cox, G.B. J. Bacteriol. (1985) [Pubmed]

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