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Gene Review:

metR - methionine biosynthesis regulon...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3822, JW3804

Maxon, M.E. et al., Maxon, M.E. et al.

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Disease relevance of metR

The Escherichia coli metR gene has been sequenced [1].

High impact information on metR

A plasmid (pRSE562) containing the metE and metR genes of Escherichia coli was used to study the expression of these genes and the role of the MetR protein in regulating metE expression [2].
The metR gene was subcloned from pRSE562, and this plasmid, pMRIII, relieved the methionine auxotrophy of a metR mutant after transformation [2].

Chemical compound and disease context of metR

Regulation of methionine synthesis in Escherichia coli: effect of the MetR protein on the expression of the metE and metR genes [2].

Other interactions of metR

When this plasmid was used to transform either wild-type E. coli, metE mutant, or metR mutant, MetE enzyme activity increased 5- to 7-fold over wild-type levels [2].

References

Structure-function studies on Escherichia coli MetR protein, a putative prokaryotic leucine zipper protein. Maxon, M.E., Wigboldus, J., Brot, N., Weissbach, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
Regulation of methionine synthesis in Escherichia coli: effect of the MetR protein on the expression of the metE and metR genes. Maxon, M.E., Redfield, B., Cai, X.Y., Shoeman, R., Fujita, K., Fisher, W., Stauffer, G., Weissbach, H., Brot, N. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]

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