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Gene Review:

ubiB - regulator of octaprenylphenol...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3829, JW3812, aarF, yigQ, yigR, ...

Macinga, D.R. et al., Poon, W.W. et al., Bresler, S.E. et al.

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Disease relevance of ubiB

Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis [1].
It was recently discovered that the aarF gene in Providencia stuartii is required for coenzyme Q (CoQ) biosynthesis [1].

High impact information on ubiB

The aarF or yigQR genes were unable to complement ubiD and ubiE mutations that are also present at 86 min on the E. coli chromosome [2].
The aarF locus encoded a protein that had a predicted molecular mass of 62,559 Da and that exhibited extensive amino acid similarity to the products of two adjacent open reading frames of unknown function (YigQ and YigR), located at 86 min on the Escherichia coli chromosome [2].
This result indicates that aarF (yigQR) represents a novel locus for ubiquinone production and reveals a previously unreported connection between ubiquinone biosynthesis and the regulation of gene expression [2].
Recombinational instability of F' plasmids in Escherichia coli K-12: localization of fre-sites [3].

References

Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis. Poon, W.W., Davis, D.E., Ha, H.T., Jonassen, T., Rather, P.N., Clarke, C.F. J. Bacteriol. (2000) [Pubmed]
Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii. Macinga, D.R., Cook, G.M., Poole, R.K., Rather, P.N. J. Bacteriol. (1998) [Pubmed]
Recombinational instability of F' plasmids in Escherichia coli K-12: localization of fre-sites. Bresler, S.E., Krivonogov, S.V., Lanzov, V.A. Mol. Gen. Genet. (1981) [Pubmed]

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