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Gene Review

zraR  -  fused DNA-binding response regulator in...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3996, JW3968, hydG
 
 
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Disease relevance of zraR

  • Expression of the Salmonella hydG gene in a T7 promoter/polymerase system revealed the presence of a unique 45 kDa protein band [1].
 

High impact information on zraR

  • In a detailed study of the function of HydH/G employing hycA'-'lacZ reporter gene fusions, it was shown that HydH/G indeed led to a stimulation of activation of the hycA promoter responsible for hydrogenase 3 synthesis but only when hydG is overexpressed from a plasmid in a strain lacking FhlA [2].
  • The 411 base pairs upstream from pHG40 contained a second open reading frame overlapping hydG by four bases [3].
 

Biological context of zraR

References

  1. Cloning and sequence analysis of hydrogenase regulatory genes (hydHG) from Salmonella typhimurium. Chopra, A.K., Peterson, J.W., Prasad, R. Biochim. Biophys. Acta (1991) [Pubmed]
  2. The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system. Leonhartsberger, S., Huber, A., Lottspeich, F., Böck, A. J. Mol. Biol. (2001) [Pubmed]
  3. Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12. Stoker, K., Reijnders, W.N., Oltmann, L.F., Stouthamer, A.H. J. Bacteriol. (1989) [Pubmed]
 
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