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Gene Review:

cutA - divalent-cation tolerance protein, copper...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4131, JW4097, cutA1, cycY

Fong, S.T. et al., Gupta, S.D. et al.

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Disease relevance of cutA

The cutA locus, presumably involved in copper tolerance in Escherichia coli, was characterized by a mutation leading to copper sensitivity [1].

High impact information on cutA

In addition to being required for copper tolerance, cutA affects tolerance levels to zinc, nickel, cobalt and cadmium salts [1].
Transcriptional fusions of cutA with the lux operon showed induction by copper, zinc, nickel, cobalt and, to a lesser extent, cadmium, manganese and silver salts [1].
The 3.2 kb DNA region involved in cutA was sequenced and analysed, revealing three significant open reading frames, none of which had been previously published [1].
One of these clones, pCUTFS2, also increased the copper tolerance of cutA, -C, and -E mutants, as well as that of a lipoprotein diacylglyceryl transferase (lgt) mutant of E. coli [2].

References

Molecular genetics of a chromosomal locus involved in copper tolerance in Escherichia coli K-12. Fong, S.T., Camakaris, J., Lee, B.T. Mol. Microbiol. (1995) [Pubmed]
A Salmonella typhimurium genetic locus which confers copper tolerance on copper-sensitive mutants of Escherichia coli. Gupta, S.D., Wu, H.C., Rick, P.D. J. Bacteriol. (1997) [Pubmed]

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