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Gene Review

chpB  -  toxin of the ChpB-ChpS toxin-antitoxin system

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4221, JW4184, chpBK, yjfE
 
 
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Disease relevance of chpB

 

High impact information on chpB

  • This module consists of a pair of genes, chpBI and chpBK encoding antitoxin ChpBI and toxin ChpBK, respectively [2].
  • The chpB locus is a chromosomal homolog of the pem locus, which is responsible for stable maintenance of plasmid R100 within the host cells [3].
  • These mutants grew normally, indicating that chpB is dispensable for cell growth [3].
  • We then constructed mutants with an insertion of a (cat) fragment within chpBK or chpBI on the E. coli chromosome [3].
  • The distal portion of chpBK was found to be adjacent to the ppa gene that encodes pyrophosphatase, whose map position had not been previously determined [1].
 

Biological context of chpB

References

  1. chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. Masuda, Y., Miyakawa, K., Nishimura, Y., Ohtsubo, E. J. Bacteriol. (1993) [Pubmed]
  2. Characterization of ChpBK, an mRNA interferase from Escherichia coli. Zhang, Y., Zhu, L., Zhang, J., Inouye, M. J. Biol. Chem. (2005) [Pubmed]
  3. Mapping and disruption of the chpB locus in Escherichia coli. Masuda, Y., Ohtsubo, E. J. Bacteriol. (1994) [Pubmed]
  4. Functional interactions between chpB and parD, two homologous conditional killer systems found in the Escherichia coli chromosome and in plasmid R1. Santos Sierra, S., Giraldo, R., Díaz Orejas, R. FEMS Microbiol. Lett. (1998) [Pubmed]
 
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