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Gene Review

hsdS  -  specificity determinant for hsdM and hsdR

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4338, JW4311, hsp, hss
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Disease relevance of hsdS

  • The Sau1 type I restriction-modification system is found on the chromosome of all nine sequenced strains of Staphylococcus aureus and includes a single hsdR (restriction) gene and two copies of hsdM (modification) and hsdS (sequence specificity) genes [1].

High impact information on hsdS

  • We have characterized a novel mutant of EcoDXXI, a type IC DNA restriction and modification (R-M) system, in which the specificity has been altered due to a Tn5 insertion into the middle of hsdS, the gene which encodes the polypeptide that confers DNA sequence specificity to both the restriction and the modification reactions [2].
  • We propose that the EcoDXXI mutant methylase utilizes two truncated hsdS subunits to recognize its binding site [2].
  • The hsdS gene varies in length from 1335 to 1425 base-pairs and the only regions showing obvious homology, one of about 100 base-pairs and a second of about 250 base-pairs, are highly conserved [3].

Biological context of hsdS

  • These enzymes (EcoK, EcoB and presumably EcoD) comprise three subunits of which one, that encoded by the so-called specificity gene (hsdS), is responsible for recognition of the DNA sequence specific to that system [3].


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