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Gene Review

hsdR  -  endonuclease R Type I restriction enzyme

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4340, JW4313, hsp, hsr
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Disease relevance of hsdR

  • The Sau1 type I restriction-modification system is found on the chromosome of all nine sequenced strains of Staphylococcus aureus and includes a single hsdR (restriction) gene and two copies of hsdM (modification) and hsdS (sequence specificity) genes [1].
  • The unusual high reversion from the R+ 124 to the R- 124 phenotype was observed only in E. coli strain transformed with the high-copy number plasmid pCP1005 carrying EcoR124I hsdR, M and S genes cloned, but not with strains carrying the natural conjugative plasmid R124 [2].

High impact information on hsdR


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