Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

hsdR - endonuclease R Type I restriction enzyme

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4340, JW4313, hsp, hsr

Hubácek, J. et al., Waldron, D.E. et al., Waite-Rees, P.A. et al., Baudouin, E. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of hsdR

The Sau1 type I restriction-modification system is found on the chromosome of all nine sequenced strains of Staphylococcus aureus and includes a single hsdR (restriction) gene and two copies of hsdM (modification) and hsdS (sequence specificity) genes [1].
The unusual high reversion from the R+ 124 to the R- 124 phenotype was observed only in E. coli strain transformed with the high-copy number plasmid pCP1005 carrying EcoR124I hsdR, M and S genes cloned, but not with strains carrying the natural conjugative plasmid R124 [2].

High impact information on hsdR

The nucleotide sequence of the entire fragment was determined; in addition to mrr, it includes two open reading frames, one of which encodes part of the hsdR [3].
Nucleotide sequence analysis has shown that the hsr 203J gene contains an open reading frame coding for a polypeptide of 335 amino acids [4].

References

Sau1: a novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages. Waldron, D.E., Lindsay, J.A. J. Bacteriol. (2006) [Pubmed]
Restriction endonucleases R.EcoKI and R.EcoR124I are probably located in different environments within the bacterial cell. Hubácek, J., Weiserová, M., Janscák, P., Firman, K. Folia Microbiol. (Praha) (1994) [Pubmed]
Characterization and expression of the Escherichia coli Mrr restriction system. Waite-Rees, P.A., Keating, C.J., Moran, L.S., Slatko, B.E., Hornstra, L.J., Benner, J.S. J. Bacteriol. (1991) [Pubmed]
Functional expression of a tobacco gene related to the serine hydrolase family -- esterase activity towards short-chain dinitrophenyl acylesters. Baudouin, E., Charpenteau, M., Roby, D., Marco, Y., Ranjeva, R., Ranty, B. Eur. J. Biochem. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.