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Gene Review:

udp - uridine phosphorylase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3825, JW3808

Burling, F.T. et al., Fonstein, M. et al., Walton, L. et al.

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Disease relevance of udp

Nucleotide sequence of the Escherichia coli uridine phosphorylase (udp) gene [1].

High impact information on udp

Chromosomal rearrangements that connect the udp gene and promoters of different rrn operons were obtained by this selection [2].
Tn10-mediated inversions fuse uridine phosphorylase (udp) and rRNA genes of Escherichia coli [2].
The 2.0 A crystal structure has been determined for Escherichia coli uridine phosphorylase (UP), an essential enzyme in nucleotide biosynthesis that catalyzes the phosphorolytic cleavage of the C-N glycosidic bond of uridine to ribose-1-phosphate and uracil [3].

References

Nucleotide sequence of the Escherichia coli uridine phosphorylase (udp) gene. Walton, L., Richards, C.A., Elwell, L.P. Nucleic Acids Res. (1989) [Pubmed]
Tn10-mediated inversions fuse uridine phosphorylase (udp) and rRNA genes of Escherichia coli. Fonstein, M., Nikolskaya, T., Zaporojets, D., Nikolsky, Y., Kulakauskas, S., Mironov, A. J. Bacteriol. (1994) [Pubmed]
Structure of Escherichia coli uridine phosphorylase at 2.0 A. Burling, F.T., Kniewel, R., Buglino, J.A., Chadha, T., Beckwith, A., Lima, C.D. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]

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