Chemical Compound Review:
uracil 1H-pyrimidine-2,4-dione
Synonyms:
Urazil, Pirod, Pyrod, Hybar X, Uracil-5-d, ...
- Formation of Okazaki fragments in polyoma DNA synthesis caused by misincorporation of uracil. Brynolf, K., Eliasson, R., Reichard, P. Cell (1978)
- Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. Mol, C.D., Arvai, A.S., Sanderson, R.J., Slupphaug, G., Kavli, B., Krokan, H.E., Mosbaugh, D.W., Tainer, J.A. Cell (1995)
- Uracil in DNA in megaloblastic anemia. Luzzatto, L., Falusi, A.O., Joju, E.A. N. Engl. J. Med. (1981)
- De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Fox, B.A., Bzik, D.J. Nature (2002)
- Uracil mustard in the treatment of thrombocytosis. Shamasunder, H.K., Gregory, S.A., Knospe, W.H. JAMA (1980)
- Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Barrett, T.E., Savva, R., Panayotou, G., Barlow, T., Brown, T., Jiricny, J., Pearl, L.H. Cell (1998)
- The incorporation of uracil into animal cell DNA in vitro. Grafstrom, R.H., Tseng, B.Y., Goulian, M. Cell (1978)
- In vivo synthesis and properties of uracil-containing DNA. Warner, H.R., Duncan, B.K. Nature (1978)
- Crystal structure of a dUTPase. Cedergren-Zeppezauer, E.S., Larsson, G., Nyman, P.O., Dauter, Z., Wilson, K.S. Nature (1992)
- Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli. Brégeon, D., Doddridge, Z.A., You, H.J., Weiss, B., Doetsch, P.W. Mol. Cell (2003)
- Adjuvant mitomycin and fluorouracil followed by oral uracil plus tegafur in serosa-negative gastric cancer: a randomised trial. Gastric Cancer Surgical Study Group. Nakajima, T., Nashimoto, A., Kitamura, M., Kito, T., Iwanaga, T., Okabayashi, K., Goto, M. Lancet (1999)
- Codon choice and gene expression: synonymous codons differ in their ability to direct aminoacylated-transfer RNA binding to ribosomes in vitro. Thomas, L.K., Dix, D.B., Thompson, R.C. Proc. Natl. Acad. Sci. U.S.A. (1988)
- A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Gallinari, P., Jiricny, J. Nature (1996)
- Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae. Thorsness, P.E., Fox, T.D. Nature (1990)
- A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase. Starzyk, R.M., Koontz, S.W., Schimmel, P. Nature (1982)
- Suppressible four-base glycine and proline codons in yeast. Donahue, T.F., Farabaugh, P.J., Fink, G.R. Science (1981)
- Requirement of mammalian DNA polymerase-beta in base-excision repair. Sobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., Wilson, S.H. Nature (1996)
- Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Imai, K., Slupphaug, G., Lee, W.I., Revy, P., Nonoyama, S., Catalan, N., Yel, L., Forveille, M., Kavli, B., Krokan, H.E., Ochs, H.D., Fischer, A., Durandy, A. Nat. Immunol. (2003)
- Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. Endres, M., Biniszkiewicz, D., Sobol, R.W., Harms, C., Ahmadi, M., Lipski, A., Katchanov, J., Mergenthaler, P., Dirnagl, U., Wilson, S.H., Meisel, A., Jaenisch, R. J. Clin. Invest. (2004)
- Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor. Govers, R., ten Broeke, T., van Kerkhof, P., Schwartz, A.L., Strous, G.J. EMBO J. (1999)
- Neurological disease associated with Mycoplasma pneumoniae pneumonitis: demonstration of viable Mycoplasma pneumoniae in cerebrospinal fluid and blood by radioisotopic and immunofluorescent tissue culture techniques. Bayer, A.S., Galpin, J.E., Theofilopoulos, A.N., Guze, L.B. Ann. Intern. Med. (1981)
- The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Hendrich, B., Hardeland, U., Ng, H.H., Jiricny, J., Bird, A. Nature (1999)
- Mutagenic deamination of cytosine residues in DNA. Duncan, B.K., Miller, J.H. Nature (1980)
- A ribozyme composed of only two different nucleotides. Reader, J.S., Joyce, G.F. Nature (2002)
- Chemical evolution from hydrogen cyanide: photochemical decarboxylation of orotic acid and orotate derivatives. Ferris, J.P., Joshi, P.C. Science (1978)
- Pyrimidine metabolism in Tritrichomonas foetus. Wang, C.C., Verham, R., Tzeng, S.F., Aldritt, S., Cheng, H.W. Proc. Natl. Acad. Sci. U.S.A. (1983)
- Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes. Mazzola, A., Amoruso, E., Beltrami, E., Lecca, D., Ferrario, S., Cosentino, S., Tremoli, E., Ceruti, S., Abbracchio, M.P. J. Cell. Mol. Med. (2008)
- HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle. Priet, S., Gros, N., Navarro, J.M., Boretto, J., Canard, B., Quérat, G., Sire, J. Mol. Cell (2005)
- Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Wibley, J.E., Waters, T.R., Haushalter, K., Verdine, G.L., Pearl, L.H. Mol. Cell (2003)
- B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Kavli, B., Andersen, S., Otterlei, M., Liabakk, N.B., Imai, K., Fischer, A., Durandy, A., Krokan, H.E., Slupphaug, G. J. Exp. Med. (2005)
- dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. Gadsden, M.H., McIntosh, E.M., Game, J.C., Wilson, P.J., Haynes, R.H. EMBO J. (1993)
- C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases. An, Q., Robins, P., Lindahl, T., Barnes, D.E. EMBO J. (2005)
- Pyrimidine salvage in Giardia lamblia. Aldritt, S.M., Tien, P., Wang, C.C. J. Exp. Med. (1985)
- Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay. Cleary, M.D., Meiering, C.D., Jan, E., Guymon, R., Boothroyd, J.C. Nat. Biotechnol. (2005)
- Characterization of genetic miscoding lesions caused by postmortem damage. Gilbert, M.T., Hansen, A.J., Willerslev, E., Rudbeck, L., Barnes, I., Lynnerup, N., Cooper, A. Am. J. Hum. Genet. (2003)
- Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. Ullman, B., Lee, M., Martin, D.W., Santi, D.V. Proc. Natl. Acad. Sci. U.S.A. (1978)
- Nucleic acid composition of bone marrow mononuclear cells in cobalamin deficiency. Ramsahoye, B.H., Burnett, A.K., Taylor, C. Blood (1996)