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Chemical Compound Review

SureCN216723     [(3R,4S,5R)-3,4-dihydroxy-5...

Synonyms: CHEBI:35425, AC1L3X77, 14075-00-4, 1-O-phosphono-D-ribofuranose, Ribofuranose, 1-phosphate (6CI), ...
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Disease relevance of D-ribose-1-phosphate

  • It is concluded that during intraperiplasmic growth B. bacteriovorus degrades some 20 to 40% of the ribonucleotides derived from the initial E. coli RNA into the base and ribose-1-phosphate moieties [1].

High impact information on D-ribose-1-phosphate


Biological context of D-ribose-1-phosphate


Associations of D-ribose-1-phosphate with other chemical compounds


Gene context of D-ribose-1-phosphate

  • Chicken PGM-2 activity was detected in the hybrids using cellogel electrophoresis and a substrate, ribose-1-phosphate (R-1-P), that allows the detection of PGM-1 activity in mice and PGM-2 activity in humans [11].
  • In this pathway, ribose-1-phosphate and inorganic phosphate act catalytically, being continuously regenerated by purine nucleoside phosphorylase and adenosine phosphorylase, respectively [12].

Analytical, diagnostic and therapeutic context of D-ribose-1-phosphate


  1. Metabolism of RNA-ribose by Bdellovibrio bacteriovorus during intraperiplasmic growth on Escherichia coli. Hespell, R.B., Odelson, D.A. J. Bacteriol. (1978) [Pubmed]
  2. Transport, phosphorylation, and toxicity of a tricyclic nucleoside in cultured Novikoff rat hepatoma cells and other cell lines and relase of its monophosphate by the cells. Plagemann, P.G. J. Natl. Cancer Inst. (1976) [Pubmed]
  3. Uridine phosphorylase from Novikoff rat hepatoma cells: purification, kinetic properties, and its role in uracil anabolism. McIvor, R.S., Wohlhueter, R.M., Plagemann, P.P. J. Cell. Physiol. (1985) [Pubmed]
  4. Synthesis of deoxyribomononucleotides in Mollicutes: dependence on deoxyribose-1-phosphate and PPi. McElwain, M.C., Pollack, J.D. J. Bacteriol. (1987) [Pubmed]
  5. 5'-Deoxy-5'-methylthioadenosine phosphorylase--III. Role of the enzyme in the metabolism and action of 5'-halogenated adenosine analogs. Savarese, T.M., Chu, S.H., Chu, M.Y., Parks, R.E. Biochem. Pharmacol. (1985) [Pubmed]
  6. Structure of Escherichia coli uridine phosphorylase at 2.0 A. Burling, F.T., Kniewel, R., Buglino, J.A., Chadha, T., Beckwith, A., Lima, C.D. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
  7. Purine nucleoside phosphorylase: its use in a spectroscopic assay for inorganic phosphate and for removing inorganic phosphate with the aid of phosphodeoxyribomutase. Nixon, A.E., Hunter, J.L., Bonifacio, G., Eccleston, J.F., Webb, M.R. Anal. Biochem. (1998) [Pubmed]
  8. Enzymatic preparation of [2,4,5,6,8-14C, 5'-3H]guanosine for use in biosynthetic studies of pterinoid and flavin compounds. Irby, R., Adair, W.L. Anal. Biochem. (1994) [Pubmed]
  9. Increased uptake of 5-fluorouracil by Ehrlich ascites tumor cells with some additives and metabolite analysis. Tezuka, M., Chikaraishi, Y., Tamemasa, O. J. Pharmacobio-dyn. (1982) [Pubmed]
  10. A new spectrophotometric assay for enzymes of purine metabolism. IV. Determination of adenosine deaminase. Heinz, F., Reckel, S., Pilz, R., Kalden, J.R. Enzyme (1980) [Pubmed]
  11. Gene mapping in chicken-Chinese hamster somatic cell hybrids. Serum albumin and phosphoglucomutase-2 structural genes on chicken chromosome 6. Palmer, D.K., Jones, C. J. Hered. (1986) [Pubmed]
  12. Phosphorylase-mediated mobilization of the amino group of adenine in Bacillus cereus. Mura, U., Di Martino, D., Leporini, C., Gini, S., Camici, M., Ipata, P.L. Arch. Biochem. Biophys. (1987) [Pubmed]
  13. Purification and characterization of uridine phosphorylase from the ice-nucleating bacterium, Pantoea agglomerans NBRC12686. Obata, H., Muryoi, N., Kawahara, H., Nishiyama, A. Cryo letters. (2004) [Pubmed]
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