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Gene Review

HI0719  -  hypothetical protein

Haemophilus influenzae Rd KW20

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High impact information on HI0719

  • The targeted screening approach identified six compounds that bind to HI0719 at the putative active site [1].
  • Previous studies have proposed that some HI0719 homologues may act on small molecules in the isoleucine biosynthetic path and, if this is correct, the ligand screening results presented here suggest that the interaction most likely occurs with 2-ketobutyrate and/or its unstable enamine precursor [1].


  1. Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family. Parsons, L., Bonander, N., Eisenstein, E., Gilson, M., Kairys, V., Orban, J. Biochemistry (2003) [Pubmed]
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