Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

XAGE2 - X antigen family, member 2

Homo sapiens

Synonyms: CT12.2, Cancer/testis antigen 12.2, G antigen family D member 3, GAGED3, X antigen family member 2, ...

Brinkmann, U. et al., Zendman, A.J. et al.

Zendman, Van Kraats, Weidle, Ruiter, Van Muijen,

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Disease relevance of XAGE2

XAGE-1 and XAGE-2 are expressed in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer, and a germ cell tumor [1].

High impact information on XAGE2

XAGE-1 and XAGE-2 should be evaluated as possible targets for vaccine-based therapies of cancer [1].
XAGE-2 was expressed at lower frequency in these tissues, while XAGE-3 was seen only in normal placenta [2].

References

Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. Brinkmann, U., Vasmatzis, G., Lee, B., Pastan, I. Cancer Res. (1999) [Pubmed]
The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. Zendman, A.J., Van Kraats, A.A., Weidle, U.H., Ruiter, D.J., Van Muijen, G.N. Int. J. Cancer (2002) [Pubmed]

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