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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

bro-c  -  ORF74

Mamestra configurata nucleopolyhedrovirus B

 
 
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High impact information on bro-c

  • We propose that BRO-A and BRO-C may function as DNA binding proteins that influence host DNA replication and/or transcription [1].
  • We detected BRO-A, BRO-C, and BRO-D in the histone H1 fraction using anti-BRO antibodies [1].
  • To identify essential site(s) for promoter activation, mutations were introduced to the promoter region of bro-c. Interestingly, it was shown that the pentanucleotide sequence CACGC located 30 nucleotides downstream of the RNA start site was essential for bro-c promoter activation [2].
  • Transient expression assays using genomic libraries of BmNPV indicated that the baculoviral trans-regulator IE-1 is responsible for activating the bro-c promoter [2].

References

  1. Evidence for nucleic acid binding ability and nucleosome association of Bombyx mori nucleopolyhedrovirus BRO proteins. Zemskov, E.A., Kang, W., Maeda, S. J. Virol. (2000) [Pubmed]
  2. An element downstream of the transcription start site is required for activation of Bombyx mori nucleopolyhedrovirus bro-c promoter. Suzuki, M.G., Kang, W.K., Maeda, S. Arch. Virol. (2001) [Pubmed]
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