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Gene Review

BAG2  -  BCL2-associated athanogene 2

Homo sapiens

Synonyms: BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, dJ417I1.2
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Disease relevance of BAG2

  • We investigated the rate-limiting steps in production of LacZ-encoding ecotropic (CRE BAG 2) and amphotropic (Psi-CRIP) retrovirus [1].

High impact information on BAG2

  • Binding assays indicate that BAG2 associates with CHIP as part of a ternary complex with Hsc70, and BAG2 colocalizes with CHIP under both quiescent conditions and after heat shock [2].
  • Using a proteomics approach, we have identified BAG2, a previously uncharacterized BAG domain-containing protein, as a common component of CHIP holocomplexes in vivo [2].
  • BAG-2 inhibits the ubiquitin ligase activity of CHIP by abrogating the CHIP/E2 cooperation and stimulates the chaperone-assisted maturation of CFTR [3].
  • The activity of BAG-2 resembles that of the previously characterized Hsc70 cochaperone and CHIP inhibitor HspBP1 [3].
  • We confirmed that MAPKAP kinase 2 is also required for phosphorylation of BAG2 in vivo [4].

Anatomical context of BAG2

  • 1. The distribution of static gamma-axons within and among muscle spindles of the tenuissimus muscle has been studied in the anaesthetized cat, on the basis of the effects on the responses of primary endings when bag2 or chain fibres or both are activated by static gamma-stimulation [5].
  • 2. The muscular part of the bag1 was modeled as a slow twitch, that of the bag2 as a fast twitch muscle fiber [6].

Other interactions of BAG2

  • The results of two-dimensional immunoblots suggested that the phosphorylation of BAG2 was specifically controlled in a p38 MAPK-dependent manner [4].


  1. Stoichiometric limitations in assembly of active recombinant retrovirus. Lei, P., Andreadis, S.T. Biotechnol. Bioeng. (2005) [Pubmed]
  2. Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. Dai, Q., Qian, S.B., Li, H.H., McDonough, H., Borchers, C., Huang, D., Takayama, S., Younger, J.M., Ren, H.Y., Cyr, D.M., Patterson, C. J. Biol. Chem. (2005) [Pubmed]
  3. BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Arndt, V., Daniel, C., Nastainczyk, W., Alberti, S., Höhfeld, J. Mol. Biol. Cell (2005) [Pubmed]
  4. Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate. Ueda, K., Kosako, H., Fukui, Y., Hattori, S. J. Biol. Chem. (2004) [Pubmed]
  5. The distribution of static gamma-axons in the tenuissimus muscle of the cat. Banks, R.W. J. Physiol. (Lond.) (1991) [Pubmed]
  6. A muscle spindle model for primary afferent firing based on a simulation of intrafusal mechanical events. Schaafsma, A., Otten, E., Van Willigen, J.D. J. Neurophysiol. (1991) [Pubmed]
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