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Gene Review

phi-8Lp4  -  P4

Pseudomonas phage phi8

 
 
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Disease relevance of phi-8Lp4

 

High impact information on phi-8Lp4

  • Ca2+ and Zn2+ and non-specific single-stranded RNA stimulate the NTPase activity, while Mg2+ acts as a non-competitive inhibitor, presumably via a separate Mg2+ binding site [1].
  • The nucleotide specificity and enzymatic properties of the P4 NTPase are similar to the NTP hydrolysis reaction conditions needed to translocate and condense the viral positive-sense RNAs to the procapsid particle [2].
  • This NTP-binding site is probably different from that of the unspecific viral NTPase found in protein P4 and also from that of the rNTP-specific RNA polymerase active site [3].

References

 
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