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Gene Review:

guaA - GMP synthase

Escherichia coli O157:H7 str. EDL933

Kamalakannan, V. et al., Shimaoka, M. et al.

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Disease relevance of guaA

Effects of xapA and guaA Disruption on Inosine Accumulation in Escherichia coli [1].

High impact information on guaA

PCR-mediated deletion mutagenesis and cloning identified a 120-bp fragment upstream from the guaA gene to be the actual regulator [2].
Primer extension analysis mapped the transcription start site to be the first 'G' residue of the translation start codon GTG of the guaA gene [2].

References

Effects of xapA and guaA Disruption on Inosine Accumulation in Escherichia coli. Shimaoka, M., Takenaka, Y., Mihara, Y., Kurahashi, O., Kawasaki, H., Matsui, H. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
Identification of a novel mycobacterial transcriptional regulator and its involvement in growth rate dependence and stringent control. Kamalakannan, V., Ramachandran, G., Narayanan, S., Vasan, S.K., Narayanan, P.R. FEMS Microbiol. Lett. (2002) [Pubmed]

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