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Gene Review

deoD  -  purine nucleoside phosphorylase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of deoD

  • Hence, in solution similar to the crystal, E. coli PNP is a hexameric molecule and previous suggestions for coexistence of two oligomeric forms are incorrect [1].

High impact information on deoD

  • Purine nucleoside phosphorylase (PNP) is a key enzyme of the nucleoside salvage pathway and is characterized by complex kinetics [1].
  • The proposed decay function was used to study effect of the interaction of E. coli purine nucleoside phosphorylase (PNP-I, the product of the deoD gene) with its specific inhibitor, viz. formycin A (FA), on fluorescence decays of ligand and enzyme tyrosine residues, in the presence of orthophosphate (P(i), a natural co-substrate) [2].

Analytical, diagnostic and therapeutic context of deoD


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