The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

chuA  -  outer membrane heme/hemoglobin receptor

Escherichia coli O157:H7 str. EDL933

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of chuA

  • We cloned the gene encoding an iron-regulated haem-transport protein and showed that this E. coli haem-utilization gene (chuA) encoded a 69 kDa outer membrane protein that was synthesized in response to iron limitation [1].
 

High impact information on chuA

  • Nucleotide sequence analysis of chuA revealed features characteristic of TonB-dependent, Fur-regulated, outer membrane iron-transport proteins [1].
  • Within the chuA gene, a consensus motif known as the JUMPStart (just upstream of many polysaccharide associated gene starts) sequence was found, which is shared by RfaH-affected operons [2].
 

Analytical, diagnostic and therapeutic context of chuA

  • When collections of EAEC strains isolated during case-control studies in Nigeria and Brazil were examined, no association of the presence of either chuA or iucA alone with diarrhea was seen, but both genes together were present in significantly more strains from cases than from controls in the Nigerian collection (P < 0.05) [3].

References

  1. Haem iron-transport system in enterohaemorrhagic Escherichia coli O157:H7. Torres, A.G., Payne, S.M. Mol. Microbiol. (1997) [Pubmed]
  2. Expression of hemin receptor molecule ChuA is influenced by RfaH in uropathogenic Escherichia coli strain 536. Nagy, G., Dobrindt, U., Kupfer, M., Emödy, L., Karch, H., Hacker, J. Infect. Immun. (2001) [Pubmed]
  3. Molecular epidemiology of the iron utilization genes of enteroaggregative Escherichia coli. Okeke, I.N., Scaletsky, I.C., Soars, E.H., Macfarlane, L.R., Torres, A.G. J. Clin. Microbiol. (2004) [Pubmed]
 
WikiGenes - Universities