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Gene Review

chuA  -  outer membrane heme/hemoglobin receptor

Escherichia coli O157:H7 str. EDL933

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Disease relevance of chuA

  • We cloned the gene encoding an iron-regulated haem-transport protein and showed that this E. coli haem-utilization gene (chuA) encoded a 69 kDa outer membrane protein that was synthesized in response to iron limitation [1].

High impact information on chuA

  • Nucleotide sequence analysis of chuA revealed features characteristic of TonB-dependent, Fur-regulated, outer membrane iron-transport proteins [1].
  • Within the chuA gene, a consensus motif known as the JUMPStart (just upstream of many polysaccharide associated gene starts) sequence was found, which is shared by RfaH-affected operons [2].

Analytical, diagnostic and therapeutic context of chuA

  • When collections of EAEC strains isolated during case-control studies in Nigeria and Brazil were examined, no association of the presence of either chuA or iucA alone with diarrhea was seen, but both genes together were present in significantly more strains from cases than from controls in the Nigerian collection (P < 0.05) [3].


  1. Haem iron-transport system in enterohaemorrhagic Escherichia coli O157:H7. Torres, A.G., Payne, S.M. Mol. Microbiol. (1997) [Pubmed]
  2. Expression of hemin receptor molecule ChuA is influenced by RfaH in uropathogenic Escherichia coli strain 536. Nagy, G., Dobrindt, U., Kupfer, M., Emödy, L., Karch, H., Hacker, J. Infect. Immun. (2001) [Pubmed]
  3. Molecular epidemiology of the iron utilization genes of enteroaggregative Escherichia coli. Okeke, I.N., Scaletsky, I.C., Soars, E.H., Macfarlane, L.R., Torres, A.G. J. Clin. Microbiol. (2004) [Pubmed]
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