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Gene Review

PDE4DIP  -  phosphodiesterase 4D interacting protein

Homo sapiens

Synonyms: CMYA2, Cardiomyopathy-associated protein 2, KIAA0454, KIAA0477, MMGL, ...
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Disease relevance of PDE4DIP


High impact information on PDE4DIP


Biological context of PDE4DIP

  • MMGL consisted of 8 exons within a genomic sequence of over 70 kb, leading to four alternatively spliced transcripts [4].
  • Reverse transcription-PCR analysis suggested that alternative splicing from myomegalin variant 1 to variant 5 may explain, in part, the development of s-MMGL-Abs [1].

Analytical, diagnostic and therapeutic context of PDE4DIP


  1. Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. Shimada, H., Kuboshima, M., Shiratori, T., Nabeya, Y., Takeuchi, A., Takagi, H., Nomura, F., Takiguchi, M., Ochiai, T., Hiwasa, T. Int. J. Oncol. (2007) [Pubmed]
  2. Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Wilkinson, K., Velloso, E.R., Lopes, L.F., Lee, C., Aster, J.C., Shipp, M.A., Aguiar, R.C. Blood (2003) [Pubmed]
  3. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde, I., Pahlke, G., Salanova, M., Zhang, G., Wang, S., Coletti, D., Onuffer, J., Jin, S.L., Conti, M. J. Biol. Chem. (2001) [Pubmed]
  4. Isolation of novel heart-specific genes using the BodyMap database. Soejima, H., Kawamoto, S., Akai, J., Miyoshi, O., Arai, Y., Morohka, T., Matsuo, S., Niikawa, N., Kimura, A., Okubo, K., Mukai, T. Genomics (2001) [Pubmed]
  5. Radiation hybrid mapping of porcine CMYA2 and CMYA4. Xu, X.L., Xu, X.W., Fan, B., Yerle, M., Liu, B. Anim. Genet. (2005) [Pubmed]
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