Disease relevance of PDE4DIP

• Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma [1].

High impact information on PDE4DIP

• We cloned the t(1;5)(q23;q33) and showed that it fuses platelet-derived growth factor receptor beta (PDGFRB) to the coiled-coil domains of a novel partner protein, myomegalin [2].
• Immunocytochemistry and transfection studies demonstrate colocalization of PDE4D and myomegalin in the Golgi/centrosomal area of cultured cells, and in sarcomeric structures of skeletal muscle [3].
• Myomegalin expressed in COS-7 cells coimmunoprecipitated with PDE4D3 and sequestered it to particulate structures [3].
• Antibodies against the deduced sequence recognized particulate myomegalin proteins of 62 kDa in testis and 230-250 kDa in heart and skeletal muscle [3].
• Subcellular localizations of their putative proteins were determined as being in the cytoplasm for C3orf3 and in the cytoplasm and nucleus for MMGL [4].

Biological context of PDE4DIP

• MMGL consisted of 8 exons within a genomic sequence of over 70 kb, leading to four alternatively spliced transcripts [4].
• Reverse transcription-PCR analysis suggested that alternative splicing from myomegalin variant 1 to variant 5 may explain, in part, the development of s-MMGL-Abs [1].

Analytical, diagnostic and therapeutic context of PDE4DIP

• Radiation hybrid mapping of porcine CMYA2 and CMYA4 [5].

References