Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MED24 - mediator complex subunit 24

Homo sapiens

Synonyms: ARC100, Activator-recruited cofactor 100 kDa component, CRSP complex subunit 4, CRSP100, CRSP4, ...

Rachez, C. et al., Clark, J. et al., Zhang, J. et al.

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High impact information on THRAP4

Overexpression of DRIP100 in vivo resulted in a strong squelching of VDR transactivation, suggesting the sequestration of other limiting factors, including components of the DRIP complex [1].
Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors [2].
These included the HB01 histone acetyl transferase gene at 17q22-23 and the TRAP100 gene, which encodes a thyroid hormone receptor-associated protein coactivator, at 17q11-21 [3].

References

A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Rachez, C., Suldan, Z., Ward, J., Chang, C.P., Burakov, D., Erdjument-Bromage, H., Tempst, P., Freedman, L.P. Genes Dev. (1998) [Pubmed]
Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors. Zhang, J., Fondell, J.D. Mol. Endocrinol. (1999) [Pubmed]
Identification of amplified and expressed genes in breast cancer by comparative hybridization onto microarrays of randomly selected cDNA clones. Clark, J., Edwards, S., John, M., Flohr, P., Gordon, T., Maillard, K., Giddings, I., Brown, C., Bagherzadeh, A., Campbell, C., Shipley, J., Wooster, R., Cooper, C.S. Genes Chromosomes Cancer (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

MED24_ANOGA	Anopheles gambiae str. PEST
MED24	Bos taurus
MED24	Canis lupus familiaris
med24	Danio rerio
MED24	Drosophila melanogaster
MED24	Gallus gallus
MED24	Macaca mulatta
Med24	Mus musculus
MED24	Pan troglodytes
Med24	Rattus norvegicus
LOC100491557	Xenopus (Silurana) tropicalis

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