High impact information on thrap4

• These studies demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of ENS precursors in the intestine [1].
• A point mutation in trap100 causes a premature stop codon that truncates the protein, causing a loss of function [1].
• lessen encodes a zebrafish trap100 required for enteric nervous system development [1].
• Antisense-mediated knockdown of trap100 causes an identical phenotype to lsn [1].
• Using cell transplantation studies, we demonstrate that lsn/trap100 acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest derived cartilages secondarily [1].

References