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Gene Review:

MED24 - Mediator complex subunit 24

Drosophila melanogaster

Synonyms: CG7999, Dmel\CG7999, Med24, Mediator of RNA polymerase II transcription subunit 24, Trap100, ...

Kim, T.W. et al., Hong, S.K. et al., Sato, S. et al., Park, J.M. et al., Ito, M. et al.

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High impact information on MED24

Here, we show that upon heat shock the Pol II-free form of Mediator is rapidly recruited to HSF binding sites [1].
Mutation of the gene encoding the Mediator component thyroid hormone receptor-associated protein (TRAP)230/MED12 affects the development of multiple systems in zebrafish embryogenesis [2].
Recruitment of the Mediator complex by transcriptional activators is usually the key step in transcriptional activation [3].
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators [3].
Here we identify one of these proteins, encoded by the previously uncharacterized AK000411 open reading frame, as a new subunit of the mammalian Mediator complex [4].

Associations of MED24 with chemical compounds

The TRAP/SMCC/Mediator complex and thyroid hormone receptor function [5].

References

Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park, J.M., Werner, J., Kim, J.M., Lis, J.T., Kim, Y.J. Mol. Cell (2001) [Pubmed]
The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., Hukriede, N.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Kim, T.W., Kwon, Y.J., Kim, J.M., Song, Y.H., Kim, S.N., Kim, Y.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. Sato, S., Tomomori-Sato, C., Banks, C.A., Parmely, T.J., Sorokina, I., Brower, C.S., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (2003) [Pubmed]
The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Ito, M., Roeder, R.G. Trends Endocrinol. Metab. (2001) [Pubmed]

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MED24_ANOGA	Anopheles gambiae str. PEST
MED24	Bos taurus
MED24	Canis lupus familiaris
med24	Danio rerio
MED24	Gallus gallus
MED24	Homo sapiens
MED24	Macaca mulatta
Med24	Mus musculus
MED24	Pan troglodytes
Med24	Rattus norvegicus
LOC100491557	Xenopus (Silurana) tropicalis

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