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Gene Review

PJA2  -  praja ring finger 2, E3 ubiquitin protein...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase Praja-2, KIAA0438, Neurodap1, Praja2, RING finger protein 131, ...
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High impact information on PJA2

  • Among them, we focus on one downregulated gene, named Neurodap1, because this gene encodes a novel protein carrying the RING-H2 sequence motif categorized in the zinc finger family [1].
  • Therefore, Neurodap1, a newly identified protein as an axotomy-suppressed gene product, might play a significant role in synaptic communication and plasticity through the control of the formation of PSD for maintaining vital functions of nerve cells [1].
  • Amino acid sequence analysis of the 71-kDa protein PJA1 showed 52.3% identity to human PJA2 (for praja-2, also known as NEURODAP1/KIAA0438) and also a significant identity to its homologs in rat, mouse, and zebrafish [2].


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