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Gene Review:

virS - sensor histidine kinase VirS

Clostridium perfringens str. 13

Rood, J.I., Lyristis, M. et al., Ba-Thein, W. et al.

Rood,

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Disease relevance of virS

The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens [1].

High impact information on virS

The production of many of the extracellular toxins is regulated at the transcriptional level by the products of the virR and virS genes, which together comprise a two-component signal transduction system [2].
Virulence studies carried out using a mouse model implicated the virS gene in the pathogenesis of histotoxic C. perfringens infections [3].

References

The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens. Ba-Thein, W., Lyristis, M., Ohtani, K., Nisbet, I.T., Hayashi, H., Rood, J.I., Shimizu, T. J. Bacteriol. (1996) [Pubmed]
Virulence genes of Clostridium perfringens. Rood, J.I. Annu. Rev. Microbiol. (1998) [Pubmed]
Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens. Lyristis, M., Bryant, A.E., Sloan, J., Awad, M.M., Nisbet, I.T., Stevens, D.L., Rood, J.I. Mol. Microbiol. (1994) [Pubmed]

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