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Gene Review

virS  -  sensor histidine kinase VirS

Clostridium perfringens str. 13

 
 
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Disease relevance of virS

  • The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens [1].
 

High impact information on virS

  • The production of many of the extracellular toxins is regulated at the transcriptional level by the products of the virR and virS genes, which together comprise a two-component signal transduction system [2].
  • Virulence studies carried out using a mouse model implicated the virS gene in the pathogenesis of histotoxic C. perfringens infections [3].

References

  1. The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens. Ba-Thein, W., Lyristis, M., Ohtani, K., Nisbet, I.T., Hayashi, H., Rood, J.I., Shimizu, T. J. Bacteriol. (1996) [Pubmed]
  2. Virulence genes of Clostridium perfringens. Rood, J.I. Annu. Rev. Microbiol. (1998) [Pubmed]
  3. Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens. Lyristis, M., Bryant, A.E., Sloan, J., Awad, M.M., Nisbet, I.T., Stevens, D.L., Rood, J.I. Mol. Microbiol. (1994) [Pubmed]
 
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