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Gene Review:

virR - DNA-binding response regulator, LytTr family

Clostridium perfringens str. 13

Ba-Thein, W. et al., Shimizu, T. et al., Banu, S. et al., Rood, J.I., Shimizu, T. et al.

Rood,

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Disease relevance of virR

The proteins under the control of the two-component system VirR/VirS in Clostridium perfringens were analyzed by using two-dimensional gel electrophoresis of the culture supernatant from the wild type and the virR mutant [1].

High impact information on virR

The production of many of the extracellular toxins is regulated at the transcriptional level by the products of the virR and virS genes, which together comprise a two-component signal transduction system [2].
A plasmid library was constructed from C. perfringens chromosomal DNA, and the plasmids were hybridized with cDNA probes prepared from total RNA of wild-type strain 13 and its virR mutant derivative TS133 [3].
The theta-toxin structural gene, pfoA, had both a major and a very minor promoter, with the major promoter being virR/virS dependent [4].
The colA gene, which encodes the kappa-toxin, had two major promoters, only one of which was virR/virS-dependent [4].
ORF2 was designated virR, and it is suggested that the virR gene plays an important role in the pathogenicity of C. perfringens [5].

References

Proteome and transcriptome analysis of the virulence genes regulated by the VirR/VirS system in Clostridium perfringens. Shimizu, T., Shima, K., Yoshino, K., Yonezawa, K., Shimizu, T., Hayashi, H. J. Bacteriol. (2002) [Pubmed]
Virulence genes of Clostridium perfringens. Rood, J.I. Annu. Rev. Microbiol. (1998) [Pubmed]
Identification of novel VirR/VirS-regulated genes in Clostridium perfringens. Banu, S., Ohtani, K., Yaguchi, H., Swe, T., Cole, S.T., Hayashi, H., Shimizu, T. Mol. Microbiol. (2000) [Pubmed]
The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens. Ba-Thein, W., Lyristis, M., Ohtani, K., Nisbet, I.T., Hayashi, H., Rood, J.I., Shimizu, T. J. Bacteriol. (1996) [Pubmed]
The virR gene, a member of a class of two-component response regulators, regulates the production of perfringolysin O, collagenase, and hemagglutinin in Clostridium perfringens. Shimizu, T., Ba-Thein, W., Tamaki, M., Hayashi, H. J. Bacteriol. (1994) [Pubmed]

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