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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPP4R1  -  protein phosphatase 4, regulatory subunit 1

Homo sapiens

Synonyms: MEG1, PP4(Rmeg), PP4R1, Serine/threonine-protein phosphatase 4 regulatory subunit 1
 
 
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High impact information on PPP4R1

  • Interestingly, unlike other class I HDACs, HDAC3 uniquely copurifies with the catalytic and regulatory subunits of the protein serine/threonine phosphatase 4 complex (PP4c/PP4R1) [1].
  • The PP4R1 cDNA clone engineered with an N-terminal Myc tag was expressed in COS M6 cells and PP4C co-immunoprecipitated with Myc-tagged PP4R1 [2].
 

Other interactions of PPP4R1

  • Mass spectrometry analysis of the purified complex revealed two major peaks, at 35 (PP4C) and 105 kDa (PP4R1) [2].

References

  1. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Zhang, X., Ozawa, Y., Lee, H., Wen, Y.D., Tan, T.H., Wadzinski, B.E., Seto, E. Genes Dev. (2005) [Pubmed]
  2. Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. Kloeker, S., Wadzinski, B.E. J. Biol. Chem. (1999) [Pubmed]
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