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MeSH Review:

Bone Marrow Purging

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Disease relevance of Bone Marrow Purging

The system for purging bone marrow of neuroblastoma cells, including 6-hydroxydopamine (6-OHDA) and AA, was analysed with regard to the interaction of AA with 6-OHDA and its autoxidation product, hydrogen peroxide [1].

High impact information on Bone Marrow Purging

PATIENTS AND METHODS: Between August 1985 and April 1996, 28 patients underwent ABMT using a uniform ablative regimen with cyclophosphamide and total-body irradiation (TBI) and a bone marrow-purging regimen [2].
Since there are substantial differences between normal and leukemic progenitors with respect to the proportion of cycling cells and the expression of transferrin receptors, B3/25-SO6 or similar immunotoxins may have clinical application in bone marrow-purging procedures [3].
Guanine arabinoside as a bone marrow-purging agent [4].
Purging bone marrow cells with CD34 antibody, an inhibition of only about 25% was observed with regard to erythroid colonies, whereas an inhibition of about 85% was observed for CFU-GM [5].
4-hydroperoxycyclophosphamide (4-HC) is the most commonly used chemotherapeutic drug when purging bone marrow contaminated with malignant cells [6].

References

Determination of ascorbic acid by isotachophoresis with regard to its potential in neuroblastoma therapy. Gebhardt, S., Kraft, K., Lode, H.N., Niethammer, D., Schmidt, K.H., Bruchelt, G. J. Chromatogr. (1993) [Pubmed]
High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission. Freedman, A.S., Neuberg, D., Gribben, J.G., Mauch, P., Soiffer, R.J., Fisher, D.C., Anderson, K.C., Andersen, N., Schlossman, R., Kroon, M., Ritz, J., Aster, J., Nadler, L.M. J. Clin. Oncol. (1998) [Pubmed]
Cytotoxic activity of an anti-transferrin receptor immunotoxin on normal and leukemic human hematopoietic progenitors. Cazzola, M., Bergamaschi, G., Dezza, L., D'Uva, R., Ponchio, L., Rosti, V., Ascari, E. Cancer Res. (1991) [Pubmed]
Guanine arabinoside as a bone marrow-purging agent. Kurtzberg, J. Ann. N. Y. Acad. Sci. (1993) [Pubmed]
Phenotyping of peripheral blood hemopoietic progenitor cells--in vitro cultures using CD34-/CD33-immunomagnetic purging. Serke, S., Abe, Y., Kirsch, A., Huhn, D. Eur. J. Haematol. (1991) [Pubmed]
Efficacy of in vitro treatment of chronic myelogenous leukemia cell line, K562 cells, using 4-hydroperoxycyclophosphamide, alpha-interferon and gamma-interferon. Lee, J.T., Park, S., Lee, J.H., Kim, B.K., Kim, N.K. J. Korean Med. Sci. (1996) [Pubmed]

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