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Chemical Compound Review

oxidopamine     5-(2-aminoethyl)benzene- 1,2,4-triol

Synonyms: Topamine, Oxidopamina, Oxidopaminum, CHEMBL337702, CCRIS 4342, ...
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Disease relevance of oxidopamine


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Chemical compound and disease context of oxidopamine


Biological context of oxidopamine


Anatomical context of oxidopamine


Associations of oxidopamine with other chemical compounds


Gene context of oxidopamine


Analytical, diagnostic and therapeutic context of oxidopamine


  1. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Gerfen, C.R., Engber, T.M., Mahan, L.C., Susel, Z., Chase, T.N., Monsma, F.J., Sibley, D.R. Science (1990) [Pubmed]
  2. Environmental influences on body weight and behavior in developing rats after neonatal 6-hydroxydopamine. Pearson, D.E., Teicher, M.H., Shaywitz, B.A., Cohen, D.J., Young, J.G., Anderson, G.M. Science (1980) [Pubmed]
  3. 6-Hydroxydopamine potentiates acute herpes simplex virus infection of the superior cervical ganglion in mice. Price, R.W. Science (1979) [Pubmed]
  4. Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates. Tabakoff, B., Yanai, J., Ritzmann, R.F. Science (1978) [Pubmed]
  5. Partial reversal of asymmetry in microvessel neurochemical changes after ischemia by corpus callosum section. Magnoni, M.S., Kobayashi, H., Govoni, S., Battaini, F., Pasinetti, G., Trabucchi, M. Circulation (1986) [Pubmed]
  6. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. Weng, Z., Signore, A.P., Gao, Y., Wang, S., Zhang, F., Hastings, T., Yin, X.M., Chen, J. J. Biol. Chem. (2007) [Pubmed]
  7. Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo. Arenas, E., Persson, H. Nature (1994) [Pubmed]
  8. Nigral transplants reinnervating the dopamine-depleted neostriatum can sustain intracranial self-stimulation. Fray, P.J., Dunnett, S.B., Iversen, S.D., Björklund, A., Stenevi, U. Science (1983) [Pubmed]
  9. Dopamine receptor supersensitivity. Kostrzewa, R.M. Neuroscience and biobehavioral reviews. (1995) [Pubmed]
  10. Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats. Coccurello, R., Breysse, N., Amalric, M. Neuropsychopharmacology (2004) [Pubmed]
  11. Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats. Sanberg, P.R., Borlongan, C.V., Othberg, A.I., Saporta, S., Freeman, T.B., Cameron, D.F. Nat. Med. (1997) [Pubmed]
  12. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.S., Sieber, B.A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumäe, U. Nature (1996) [Pubmed]
  13. Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats. Stricker, E.M., Zimmerman, M.B., Friedman, M.I., Zigmond, M.J. Nature (1977) [Pubmed]
  14. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Choi-Lundberg, D.L., Lin, Q., Chang, Y.N., Chiang, Y.L., Hay, C.M., Mohajeri, H., Davidson, B.L., Bohn, M.C. Science (1997) [Pubmed]
  15. Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine. Acheson, A.L., Zigmond, M.J., Stricker, E.M. Science (1980) [Pubmed]
  16. Pulmonary vasodilator responses to vagal stimulation and acetylcholine in the cat. Nandiwada, P.A., Hyman, A.L., Kadowitz, P.J. Circ. Res. (1983) [Pubmed]
  17. Ascorbic acid enhances the effects of 6-hydroxydopamine and H2O2 on iron-dependent DNA strand breaks and related processes in the neuroblastoma cell line SK-N-SH. Bruchelt, G., Schraufstätter, I.U., Niethammer, D., Cochrane, C.G. Cancer Res. (1991) [Pubmed]
  18. Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanisms. Robertson, G.S., Robertson, H.A. J. Neurosci. (1989) [Pubmed]
  19. Dopamine depletion reorganizes projections from the nucleus accumbens and ventral pallidum that mediate opioid-induced motor activity. Churchill, L., Klitenick, M.A., Kalivas, P.W. J. Neurosci. (1998) [Pubmed]
  20. Sympathectomy, which induces membranous bone remodeling, has no effect on endochondral long bone remodeling in vivo. Sherman, B.E., Chole, R.A. J. Bone Miner. Res. (2000) [Pubmed]
  21. Behavioural supersensitivity following neonatal 6-hydroxydopamine: attenuation by MK-801. Archer, T., Fredriksson, A. Neurotox. Res (2007) [Pubmed]
  22. Glucoregulatory feeding by rats after intraventricular 6-hydroxydopamine or lateral hypothalamic lesions. Stricker, E.M., Friedman, M.I., Zigmond, M.J. Science (1975) [Pubmed]
  23. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Fisher, L.J., Jinnah, H.A., Kale, L.C., Higgins, G.A., Gage, F.H. Neuron (1991) [Pubmed]
  24. Dopaminergic control of 125I-labeled neurotensin binding site density in corticolimbic structures of the rat brain. Herve, D., Tassin, J.P., Studler, J.M., Dana, C., Kitabgi, P., Vincent, J.P., Glowinski, J., Rostene, W. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Cole, D.G., Kobierski, L.A., Konradi, C., Hyman, S.E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  26. Depletion of brain catecholamines: failure of ocular dominance shift after monocular occlusion in kittens. Kasamatsu, T., Pettigrew, J.D. Science (1976) [Pubmed]
  27. beta-Adrenergic receptor involvement in 6-hydroxydopamine-induced supersensitivity in rat cerebral cortex. Sporn, J.R., Harden, T.K., Wolfe, B.B., Molinoff, P.B. Science (1976) [Pubmed]
  28. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Milbrandt, J., de Sauvage, F.J., Fahrner, T.J., Baloh, R.H., Leitner, M.L., Tansey, M.G., Lampe, P.A., Heuckeroth, R.O., Kotzbauer, P.T., Simburger, K.S., Golden, J.P., Davies, J.A., Vejsada, R., Kato, A.C., Hynes, M., Sherman, D., Nishimura, M., Wang, L.C., Vandlen, R., Moffat, B., Klein, R.D., Poulsen, K., Gray, C., Garces, A., Johnson, E.M. Neuron (1998) [Pubmed]
  29. GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Arenas, E., Trupp, M., Akerud, P., Ibáñez, C.F. Neuron (1995) [Pubmed]
  30. Platelet-induced neurogenic coronary contractions due to accumulation of the false neurotransmitter, 5-hydroxytryptamine. Cohen, R.A. J. Clin. Invest. (1985) [Pubmed]
  31. Prolonged contraction duration in aged myocardium. Lakatta, E.G., Gerstenblith, G., Angell, C.S., Shock, N.W., Weisfeldt, M.L. J. Clin. Invest. (1975) [Pubmed]
  32. Adenosine release may mediate spinal analgesia by morphine. Sawynok, J., Sweeney, M.I., White, T.D. Trends Pharmacol. Sci. (1989) [Pubmed]
  33. Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. Dumartin, B., Jaber, M., Gonon, F., Caron, M.G., Giros, B., Bloch, B. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  34. Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity. Offen, D., Beart, P.M., Cheung, N.S., Pascoe, C.J., Hochman, A., Gorodin, S., Melamed, E., Bernard, R., Bernard, O. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  35. Catecholaminergic properties of cholinergic neurons and synapses in adult rat ciliary ganglion. Landis, S.C., Jackson, P.C., Fredieu, J.R., Thibault, J. J. Neurosci. (1987) [Pubmed]
  36. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. da Costa, C.A., Masliah, E., Checler, F. J. Biol. Chem. (2003) [Pubmed]
  37. Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. Choi, W.S., Eom, D.S., Han, B.S., Kim, W.K., Han, B.H., Choi, E.J., Oh, T.H., Markelonis, G.J., Cho, J.W., Oh, Y.J. J. Biol. Chem. (2004) [Pubmed]
  38. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. Rosenblad, C., Grønborg, M., Hansen, C., Blom, N., Meyer, M., Johansen, J., Dagø, L., Kirik, D., Patel, U.A., Lundberg, C., Trono, D., Björklund, A., Johansen, T.E. Mol. Cell. Neurosci. (2000) [Pubmed]
  39. Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. Altar, C.A., Boylan, C.B., Fritsche, M., Jones, B.E., Jackson, C., Wiegand, S.J., Lindsay, R.M., Hyman, C. J. Neurochem. (1994) [Pubmed]
  40. Compensations after lesions of central dopaminergic neurons: some clinical and basic implications. Zigmond, M.J., Abercrombie, E.D., Berger, T.W., Grace, A.A., Stricker, E.M. Trends Neurosci. (1990) [Pubmed]
  41. Cardiac epinephrine synthesis. Regulation by a glucocorticoid. Kennedy, B., Ziegler, M.G. Circulation (1991) [Pubmed]
  42. Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor gene. Le Moine, C., Normand, E., Bloch, B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  43. Differential downregulation of beta 2-adrenergic receptors in tissue compartments of rat heart is not altered by sympathetic denervation. Zhao, M., Muntz, K.H. Circ. Res. (1993) [Pubmed]
  44. Depression of endothelial nitric oxide synthase but increased expression of endothelin-1 immunoreactivity in rat thoracic aortic endothelium associated with long-term, but not short-term, sympathectomy. Aliev, G., Ralevic, V., Burnstock, G. Circ. Res. (1996) [Pubmed]
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