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MeSH Review:

Postpoliomyelitis Syndrome

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High impact information on Postpoliomyelitis Syndrome

The patients with post-polio syndrome had significantly higher mean (+/- SD) (cerebrospinal fluid levels of interleukin-2 and soluble interleukin-2 receptors than the controls (8.1 +/- 5.3 vs. 1.4 +/- 0.8 U per milliliter and 159.6 +/- 102.9 vs. 10.7 +/- 6.2 U per milliliter, respectively) [1].
OBJECTIVES: To investigate the effect of pyridostigmine on fatigue, physical performance, and muscle function in subjects with postpoliomyelitis syndrome [2].
Absence of SMN gene deletion in post-polio syndrome [3].
SCICP reported comparable levels of LI, LC, AD, S, SR, but greater levels of PS compared with a group of people with post-polio syndrome [4].
A double-blind, placebo-controlled trial of amantadine for the treatment of fatigue in patients with the post-polio syndrome [5].

Chemical compound and disease context of Postpoliomyelitis Syndrome

A double-blind, placebo-controlled trial of high-dose prednisone for the treatment of post-poliomyelitis syndrome [6].
Effects of lamotrigine on the symptoms and life qualities of patients with post polio syndrome: a randomized, controlled study [7].

Gene context of Postpoliomyelitis Syndrome

Low IGF-I levels in subjects with post-polio syndrome were corrected by physiologic doses of hGH and the response was dose dependent [8].

References

Intrathecal immune response in patients with the post-polio syndrome. Sharief, M.K., Hentges, R., Ciardi, M. N. Engl. J. Med. (1991) [Pubmed]
Pyridostigmine in postpolio syndrome: no decline in fatigue and limited functional improvement. Horemans, H.L., Nollet, F., Beelen, A., Drost, G., Stegeman, D.F., Zwarts, M.J., Bussmann, J.B., de Visser, M., Lankhorst, G.J. J. Neurol. Neurosurg. Psychiatr. (2003) [Pubmed]
Absence of SMN gene deletion in post-polio syndrome. Bartholdi, D., Gonzalez, H., Borg, K., Melki, J. Neuromuscul. Disord. (2000) [Pubmed]
Psychosocial profiles of people with pain associated with spinal cord injury: identification and comparison with other chronic pain syndromes. Widerström-Noga, E.G., Duncan, R., Turk, D.C. The Clinical journal of pain. (2004) [Pubmed]
A double-blind, placebo-controlled trial of amantadine for the treatment of fatigue in patients with the post-polio syndrome. Stein, D.P., Dambrosia, J.M., Dalakas, M.C. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
A double-blind, placebo-controlled trial of high-dose prednisone for the treatment of post-poliomyelitis syndrome. Dinsmore, S., Dambrosia, J., Dalakas, M.C. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
Effects of lamotrigine on the symptoms and life qualities of patients with post polio syndrome: a randomized, controlled study. On, A.Y., Oncu, J., Uludag, B., Ertekin, C. NeuroRehabilitation. (2005) [Pubmed]
Studies of growth hormone/insulin-like growth factor-I in polio survivors. Shetty, K.R., Rao, U.P., Gupta, K.L., Rudman, D. Ann. N. Y. Acad. Sci. (1995) [Pubmed]

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