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MeSH Review:

Quality of Life

Berenson, J.R. et al., Fletcher, A. et al., Testa, M.A. et al., Suurmeijer, T.P. et al., Cohn, J.N. et al., et al.

Lipsky, van der Heijde, St Clair, Furst, Breedveld, Kalden, Smolen, Weisman, Emery, Feldmann, Harriman, Maini, Rapaport, Pollack, Wolkow, Mardekian, Clary, Taylor, Myers, Simpson, McPherson, Weatherall, Bartlett, Piedmont, Bilderback, Matsumoto, Bathon, Knudtson, Wyse, Galbraith, Brant, Hildebrand, Paterson, Richardson, Burkart, Burgess, Hlatky, Boothroyd, Vittinghoff, Sharp, Whooley, Howard, Metz, Stern, Kris-Etherton, Reusser, Morris, Hatton, Oparil, Haynes, Resnick, Pi-Sunyer, Clark, Chester, McMahon, Snyder, McCarron, Backonja, Beydoun, Edwards, Schwartz, Fonseca, Hes, LaMoreaux, Garofalo, Seidenfeld, Piper, Flamm, Hasselblad, Armitage, Bennett, Gordon, Lichtin, Wade, Woolf, Aronson,

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Disease relevance of Quality of Life

Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group [1].
Treatment with valsartan also resulted in significant improvements in NYHA class, ejection fraction, signs and symptoms of heart failure, and quality of life as compared with placebo (P<0.01) [2].
Secondary outcomes were the use of prednisone and 5-amino-salicylates, mean score on the Crohn's Disease Activity Index and mean quality-of-life score, and the need for surgery [3].
Monthly infusions of pamidronate provide significant protection against skeletal complications and improve the quality of life of patients with stage III multiple myeloma [4].
Our results suggest a possible role for megestrol acetate in reversing anorexia and weight loss, thereby improving the quality of life of patients with cachexia [5].

Psychiatry related information on Quality of Life

Quality of life of people with rheumatoid arthritis as measured by the World Health Organization Quality of Life Instrument, short form (WHOQOL-BREF): score distributions and psychometric properties [6].
Spirituality, well-being, and quality of life in people with rheumatoid arthritis [7].
OBJECTIVE: The authors used seven definitions of response in panic disorder to compare patient-rated improvements in quality of life between patients with panic disorder who responded to sertraline and those who responded to placebo [8].
Health-related quality of life measured with the 36-item short-form health survey revealed significantly decreased scores for physical role function, bodily pain, vitality, social function, emotional role function, and mental health in patients with PCOS [9].
Data were collected at pre-intervention and at 3 months following the use of the Self-Efficacy for Diabetes scale, Children's Depression Inventory, Issues in Coping with IDDM scale, and the Diabetes Quality of Life: Youth scale [10].

High impact information on Quality of Life

Adding irinotecan to the regimen of fluorouracil and leucovorin did not compromise the quality of life [11].
The quality of life was also significantly better with infliximab plus methotrexate than with methotrexate alone [12].
The severity of angina (according to the Canadian Cardiovascular Society [CCS] classification), quality of life, and cardiac perfusion (as assessed by thallium-201 scanning) were evaluated at base line and 3, 6, and 12 months after randomization [13].
Trends in mortality and in measures of the quality of life in the 30-mg vesnarinone group were similar to those in the 60-mg group but not significantly different from those in the placebo group [14].
Growth hormone also improved clinical symptoms, exercise capacity, and the patients' quality of life [15].

Chemical compound and disease context of Quality of Life

IIP reduced blood glucose fluctuations compared with MDI (P<.001), and reduced the incidence of mild clinical hypoglycemia by 68% (P<.001); IIP also eliminated the weight gain associated with MDI therapy and yielded better overall quality-of-life (P=.03) and impact-of-disease subscale scores (P=.05) [16].
CONCLUSION: Gabapentin monotherapy appears to be efficacious for the treatment of pain and sleep interference associated with diabetic peripheral neuropathy and exhibits positive effects on mood and quality of life [17].
OBJECTIVE: To determine if current EDTA protocols have a favorable impact on exercise ischemia threshold and quality of life measures in patients with stable ischemic heart disease [18].
To help document the achievement of palliation and to characterize positive and negative effects of treatment, we evaluated quality-of-life (QOL) parameters in patients with metastatic prostate cancer who were randomly assigned to two methods of androgen deprivation [19].
Raltitrexed showed similar response rates and overall survival to the de Gramont regimen and was easier to administer, but resulted in greater toxicity and inferior quality of life [20].

Biological context of Quality of Life

There were no significant differences between the two groups in peak flow variability, forced expiratory volume in one second, the number of puffs of supplemental albuterol needed, asthma symptoms, asthma quality-of-life score, or airway responsiveness to methacholine [21].
OBJECTIVE: To investigate the effects of physiologic testosterone administration on body composition, exercise functional capacity, and quality of life in androgen-deficient men with the AIDS wasting syndrome [22].
In contrast, carvedilol therapy had little effect on indirect measures of patient benefit, including changes in exercise tolerance or quality-of-life scores [23].
Secondary measures were changes in blood pressure or plasma lipid, lipoprotein, glucose, or glycosylated hemoglobin levels; quality of life; nutrient intake; and dietary compliance [24].
Long-term carvedilol administration also improved rest left ventricular ejection fraction (from 20 +/- 7% to 30 +/- 12%, p < 0.001), submaximal exercise capacity, quality of life and New York Heart Association functional class [25].

Anatomical context of Quality of Life

OBJECTIVE: To determine the effect on quality of life of estrogen plus progestin therapy used as secondary prevention in women with coronary artery disease [26].
OBJECTIVE--To evaluate the impact of long-term granulocyte colony-stimulating factor (GCSF) treatment on quality of life of patients with congenital, cyclic, or idiopathic neutropenia [27].
Pancreas transplantation can correct severe metabolic instability and thus improve quality of life, but it cannot yet be recommended for the treatment of established lesions of diabetic nephropathy [28].
Health-related quality of life and seizure control in temporal lobe epilepsy [29].
OBJECTIVE: The aim of this study was to examine the quality of life (QoL) profiles of patients with early rheumatoid arthritis (RA) and to relate these to disease and impairment variables as indicated, respectively, by erythrocyte sedimentation rate (ESR) and by tender joint count (Ritchie Articular Index), fatigue, and pain [30].

Associations of Quality of Life with chemical compounds

Captopril, enalapril, and quality of life [31].
Captopril, enalapril, and quality of life [32].
Two angiotensin-converting-enzyme inhibitors, captopril and enalapril, indistinguishable according to clinical assessments of efficacy and safety, had different effects on quality of life [1].
Zidovudine and the quality of life [33].
The patients who received pamidronate had significant decreases in bone pain and no deterioration in performance status and quality of life [4].

Gene context of Quality of Life

A multicenter randomized controlled trial was performed to assess the role of high-dose TMX versus placebo (P) in the treatment of patients with inoperable HCC with respect to survival and quality of life (QoL) [34].
CONCLUSION: Among women who test positive for a BRCA1 or BRCA2 gene mutation, prophylactic surgery at a young age substantially improves survival, but unless genetic risk of cancer is high, provides no benefit for quality of life [35].
METHODS: Data from an ongoing longitudinal, observational study in Norway were used to assess changes in health-related quality of life (HRQOL) in patients with RA (n = 291) and AS (n = 62) [36].
Reduced indirect costs through improved disability scores and improved health-related quality of life are also predictable with the use of COX-2-specific inhibitors [37].
In summary, epoetin alfa is an effective alternative to blood transfusion, reducing anaemia and producing consequent improvements in quality of life in many nonrenal applications [38].

Analytical, diagnostic and therapeutic context of Quality of Life

Only studies with mean baseline hemoglobin concentrations of 10 g/dL or less reported statistically significant effects of epoetin treatment on quality of life; quality-of-life data were insufficient for meta-analysis [39].
In a randomised controlled trial in 427 men with chronic stable angina continuous use of 5 mg transdermal glyceryl trinitrate (GTN) showed no advantage over placebo in terms of efficacy (anginal attack rates and sublingual GTN consumption) or quality of life (as measured with the sickness impact profile and a health index of disability) [40].
Home parenteral nutrition: survival, cost, and quality of life [41].
Serum bilirubin, quality of life, and survival time were assessed in two monthly intervals after photodynamic therapy [42].
Sclerotherapy was significantly less cost-effective than propranolol and had no advantage on quality of life [43].

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