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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Quality of Life

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Disease relevance of Quality of Life


Psychiatry related information on Quality of Life


High impact information on Quality of Life


Chemical compound and disease context of Quality of Life

  • IIP reduced blood glucose fluctuations compared with MDI (P<.001), and reduced the incidence of mild clinical hypoglycemia by 68% (P<.001); IIP also eliminated the weight gain associated with MDI therapy and yielded better overall quality-of-life (P=.03) and impact-of-disease subscale scores (P=.05) [16].
  • CONCLUSION: Gabapentin monotherapy appears to be efficacious for the treatment of pain and sleep interference associated with diabetic peripheral neuropathy and exhibits positive effects on mood and quality of life [17].
  • OBJECTIVE: To determine if current EDTA protocols have a favorable impact on exercise ischemia threshold and quality of life measures in patients with stable ischemic heart disease [18].
  • To help document the achievement of palliation and to characterize positive and negative effects of treatment, we evaluated quality-of-life (QOL) parameters in patients with metastatic prostate cancer who were randomly assigned to two methods of androgen deprivation [19].
  • Raltitrexed showed similar response rates and overall survival to the de Gramont regimen and was easier to administer, but resulted in greater toxicity and inferior quality of life [20].

Biological context of Quality of Life


Anatomical context of Quality of Life


Associations of Quality of Life with chemical compounds


Gene context of Quality of Life

  • A multicenter randomized controlled trial was performed to assess the role of high-dose TMX versus placebo (P) in the treatment of patients with inoperable HCC with respect to survival and quality of life (QoL) [34].
  • CONCLUSION: Among women who test positive for a BRCA1 or BRCA2 gene mutation, prophylactic surgery at a young age substantially improves survival, but unless genetic risk of cancer is high, provides no benefit for quality of life [35].
  • METHODS: Data from an ongoing longitudinal, observational study in Norway were used to assess changes in health-related quality of life (HRQOL) in patients with RA (n = 291) and AS (n = 62) [36].
  • Reduced indirect costs through improved disability scores and improved health-related quality of life are also predictable with the use of COX-2-specific inhibitors [37].
  • In summary, epoetin alfa is an effective alternative to blood transfusion, reducing anaemia and producing consequent improvements in quality of life in many nonrenal applications [38].

Analytical, diagnostic and therapeutic context of Quality of Life


  1. Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group. Testa, M.A., Anderson, R.B., Nackley, J.F., Hollenberg, N.K. N. Engl. J. Med. (1993) [Pubmed]
  2. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. Cohn, J.N., Tognoni, G. N. Engl. J. Med. (2001) [Pubmed]
  3. Low-dose cyclosporine for the treatment of Crohn's disease. The Canadian Crohn's Relapse Prevention Trial Investigators. Feagan, B.G., McDonald, J.W., Rochon, J., Laupacis, A., Fedorak, R.N., Kinnear, D., Saibil, F., Groll, A., Archambault, A., Gillies, R. N. Engl. J. Med. (1994) [Pubmed]
  4. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. Berenson, J.R., Lichtenstein, A., Porter, L., Dimopoulos, M.A., Bordoni, R., George, S., Lipton, A., Keller, A., Ballester, O., Kovacs, M.J., Blacklock, H.A., Bell, R., Simeone, J., Reitsma, D.J., Heffernan, M., Seaman, J., Knight, R.D. N. Engl. J. Med. (1996) [Pubmed]
  5. High-dose megestrol acetate. A possible treatment for cachexia. Tchekmedyian, N.S., Tait, N., Moody, M., Aisner, J. JAMA (1987) [Pubmed]
  6. Quality of life of people with rheumatoid arthritis as measured by the World Health Organization Quality of Life Instrument, short form (WHOQOL-BREF): score distributions and psychometric properties. Taylor, W.J., Myers, J., Simpson, R.T., McPherson, K.M., Weatherall, M. Arthritis Rheum. (2004) [Pubmed]
  7. Spirituality, well-being, and quality of life in people with rheumatoid arthritis. Bartlett, S.J., Piedmont, R., Bilderback, A., Matsumoto, A.K., Bathon, J.M. Arthritis Rheum. (2003) [Pubmed]
  8. Is placebo response the same as drug response in panic disorder? Rapaport, M.H., Pollack, M., Wolkow, R., Mardekian, J., Clary, C. The American journal of psychiatry. (2000) [Pubmed]
  9. Quality of life, psychosocial well-being, and sexual satisfaction in women with polycystic ovary syndrome. Elsenbruch, S., Hahn, S., Kowalsky, D., Offner, A.H., Schedlowski, M., Mann, K., Janssen, O.E. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  10. Short-term effects of coping skills training as adjunct to intensive therapy in adolescents. Grey, M., Boland, E.A., Davidson, M., Yu, C., Sullivan-Bolyai, S., Tamborlane, W.V. Diabetes Care (1998) [Pubmed]
  11. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. Saltz, L.B., Cox, J.V., Blanke, C., Rosen, L.S., Fehrenbacher, L., Moore, M.J., Maroun, J.A., Ackland, S.P., Locker, P.K., Pirotta, N., Elfring, G.L., Miller, L.L. N. Engl. J. Med. (2000) [Pubmed]
  12. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. Lipsky, P.E., van der Heijde, D.M., St Clair, E.W., Furst, D.E., Breedveld, F.C., Kalden, J.R., Smolen, J.S., Weisman, M., Emery, P., Feldmann, M., Harriman, G.R., Maini, R.N. N. Engl. J. Med. (2000) [Pubmed]
  13. Transmyocardial revascularization with a carbon dioxide laser in patients with end-stage coronary artery disease. Frazier, O.H., March, R.J., Horvath, K.A. N. Engl. J. Med. (1999) [Pubmed]
  14. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators. Cohn, J.N., Goldstein, S.O., Greenberg, B.H., Lorell, B.H., Bourge, R.C., Jaski, B.E., Gottlieb, S.O., McGrew, F., DeMets, D.L., White, B.G. N. Engl. J. Med. (1998) [Pubmed]
  15. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. Fazio, S., Sabatini, D., Capaldo, B., Vigorito, C., Giordano, A., Guida, R., Pardo, F., Biondi, B., Saccà, L. N. Engl. J. Med. (1996) [Pubmed]
  16. Implantable insulin pump vs multiple-dose insulin for non-insulin-dependent diabetes mellitus: a randomized clinical trial. Department of Veterans Affairs Implantable Insulin Pump Study Group. Saudek, C.D., Duckworth, W.C., Giobbie-Hurder, A., Henderson, W.G., Henry, R.R., Kelley, D.E., Edelman, S.V., Zieve, F.J., Adler, R.A., Anderson, J.W., Anderson, R.J., Hamilton, B.P., Donner, T.W., Kirkman, M.S., Morgan, N.A. JAMA (1996) [Pubmed]
  17. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. Backonja, M., Beydoun, A., Edwards, K.R., Schwartz, S.L., Fonseca, V., Hes, M., LaMoreaux, L., Garofalo, E. JAMA (1998) [Pubmed]
  18. Chelation therapy for ischemic heart disease: a randomized controlled trial. Knudtson, M.L., Wyse, D.G., Galbraith, P.D., Brant, R., Hildebrand, K., Paterson, D., Richardson, D., Burkart, C., Burgess, E. JAMA (2002) [Pubmed]
  19. Quality of life in advanced prostate cancer: results of a randomized therapeutic trial. Moinpour, C.M., Savage, M.J., Troxel, A., Lovato, L.C., Eisenberger, M., Veith, R.W., Higgins, B., Skeel, R., Yee, M., Blumenstein, B.A., Crawford, E.D., Meyskens, F.L. J. Natl. Cancer Inst. (1998) [Pubmed]
  20. Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial. Maughan, T.S., James, R.D., Kerr, D.J., Ledermann, J.A., McArdle, C., Seymour, M.T., Cohen, D., Hopwood, P., Johnston, C., Stephens, R.J. Lancet (2002) [Pubmed]
  21. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. Drazen, J.M., Israel, E., Boushey, H.A., Chinchilli, V.M., Fahy, J.V., Fish, J.E., Lazarus, S.C., Lemanske, R.F., Martin, R.J., Peters, S.P., Sorkness, C., Szefler, S.J. N. Engl. J. Med. (1996) [Pubmed]
  22. Effects of androgen administration in men with the AIDS wasting syndrome. A randomized, double-blind, placebo-controlled trial. Grinspoon, S., Corcoran, C., Askari, H., Schoenfeld, D., Wolf, L., Burrows, B., Walsh, M., Hayden, D., Parlman, K., Anderson, E., Basgoz, N., Klibanski, A. Ann. Intern. Med. (1998) [Pubmed]
  23. Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure. The PRECISE Trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise. Packer, M., Colucci, W.S., Sackner-Bernstein, J.D., Liang, C.S., Goldscher, D.A., Freeman, I., Kukin, M.L., Kinhal, V., Udelson, J.E., Klapholz, M., Gottlieb, S.S., Pearle, D., Cody, R.J., Gregory, J.J., Kantrowitz, N.E., LeJemtel, T.H., Young, S.T., Lukas, M.A., Shusterman, N.H. Circulation (1996) [Pubmed]
  24. A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients: impact on cardiovascular risk reduction. Metz, J.A., Stern, J.S., Kris-Etherton, P., Reusser, M.E., Morris, C.D., Hatton, D.C., Oparil, S., Haynes, R.B., Resnick, L.M., Pi-Sunyer, F.X., Clark, S., Chester, L., McMahon, M., Snyder, G.W., McCarron, D.A. Arch. Intern. Med. (2000) [Pubmed]
  25. Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy. Metra, M., Nardi, M., Giubbini, R., Dei Cas, L. J. Am. Coll. Cardiol. (1994) [Pubmed]
  26. Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial. Hlatky, M.A., Boothroyd, D., Vittinghoff, E., Sharp, P., Whooley, M.A. JAMA (2002) [Pubmed]
  27. Quality of life of patients with severe chronic neutropenia receiving long-term treatment with granulocyte colony-stimulating factor. Jones, E.A., Bolyard, A.A., Dale, D.C. JAMA (1993) [Pubmed]
  28. Effects of pancreas transplantation on glomerular structure in insulin-dependent diabetic patients with their own kidneys. Fioretto, P., Mauer, S.M., Bilous, R.W., Goetz, F.C., Sutherland, D.E., Steffes, M.W. Lancet (1993) [Pubmed]
  29. Health-related quality of life and seizure control in temporal lobe epilepsy. McLachlan, R.S., Rose, K.J., Derry, P.A., Bonnar, C., Blume, W.T., Girvin, J.P. Ann. Neurol. (1997) [Pubmed]
  30. Quality of life profiles in the first years of rheumatoid arthritis: results from the EURIDISS longitudinal study. Suurmeijer, T.P., Waltz, M., Moum, T., Guillemin, F., van Sonderen, F.L., Briançon, S., Sanderman, R., van den Heuvel, W.J. Arthritis Rheum. (2001) [Pubmed]
  31. Captopril, enalapril, and quality of life. Santanello, N.C., Guess, H., Heyse, J.F. N. Engl. J. Med. (1993) [Pubmed]
  32. Captopril, enalapril, and quality of life. Waud, D.R. N. Engl. J. Med. (1993) [Pubmed]
  33. Zidovudine and the quality of life. Berman, D.S., Wenglin, B.D. N. Engl. J. Med. (1994) [Pubmed]
  34. High-dose tamoxifen in the treatment of inoperable hepatocellular carcinoma: A multicenter randomized controlled trial. Chow, P.K., Tai, B.C., Tan, C.K., Machin, D., Win, K.M., Johnson, P.J., Soo, K.C. Hepatology (2002) [Pubmed]
  35. Decision analysis of prophylactic mastectomy and oophorectomy in BRCA1-positive or BRCA2-positive patients. Grann, V.R., Panageas, K.S., Whang, W., Antman, K.H., Neugut, A.I. J. Clin. Oncol. (1998) [Pubmed]
  36. The comparative effectiveness of tumor necrosis factor-blocking agents in patients with rheumatoid arthritis and patients with ankylosing spondylitis: a six-month, longitudinal, observational, multicenter study. Heiberg, M.S., Nordvåg, B.Y., Mikkelsen, K., Rødevand, E., Kaufmann, C., Mowinckel, P., Kvien, T.K. Arthritis Rheum. (2005) [Pubmed]
  37. The economic implications of cyclooxygenase-2-specific inhibitors. Peloso, P.M., Scheiman, J.M. Am. J. Med. (2001) [Pubmed]
  38. Epoetin alfa. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in nonrenal applications. Markham, A., Bryson, H.M. Drugs (1995) [Pubmed]
  39. Epoetin treatment of anemia associated with cancer therapy: a systematic review and meta-analysis of controlled clinical trials. Seidenfeld, J., Piper, M., Flamm, C., Hasselblad, V., Armitage, J.O., Bennett, C.L., Gordon, M.S., Lichtin, A.E., Wade, J.L., Woolf, S., Aronson, N. J. Natl. Cancer Inst. (2001) [Pubmed]
  40. Quality of life on angina therapy: a randomised controlled trial of transdermal glyceryl trinitrate against placebo. Fletcher, A., McLoone, P., Bulpitt, C. Lancet (1988) [Pubmed]
  41. Home parenteral nutrition: survival, cost, and quality of life. Howard, L. Gastroenterology (2006) [Pubmed]
  42. Photodynamic therapy of nonresectable cholangiocarcinoma. Ortner, M.A., Liebetruth, J., Schreiber, S., Hanft, M., Wruck, U., Fusco, V., Müller, J.M., Hörtnagl, H., Lochs, H. Gastroenterology (1998) [Pubmed]
  43. Primary prophylaxis of variceal bleeding in cirrhosis: a cost-effectiveness analysis. Teran, J.C., Imperiale, T.F., Mullen, K.D., Tavill, A.S., McCullough, A.J. Gastroenterology (1997) [Pubmed]
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