Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

MeSH Review:

Nevus, Epithelioid and Spindle Cell

Harris, M.N. et al., Harvell, J.D. et al., Kato, N. et al., Tu, P. et al., Hoang, M.P., et al.

Isabel Zhu, Fitzpatrick, Hoang,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nevus, Epithelioid and Spindle Cell

Use of Bayes rule and MIB-1 proliferation index to discriminate Spitz nevus from malignant melanoma [1].
CONCLUSIONS: Congenital Spitz nevi are true congenital lesions, with histopathologic features of both acquired Spitz nevus and superficial congenital melanocytic nevus [2].

High impact information on Nevus, Epithelioid and Spindle Cell

This study investigated the ability of high-resolution array-based CGH to serve as a diagnostic test in distinguishing Spitz nevus and melanoma using DNA isolated from formalin-fixed and paraffin-embedded samples [3].
Expression of proliferating cell nuclear antigen in Spitz nevus [4].
CONCLUSIONS: CD117 is unlikely a useful diagnostic tool in differentiating Spitz nevus from primary MM [5].
BACKGROUND: The deposition of extracellular mucin has not been described in Spitz nevus and herein such a case is reported [6].
Unexpectedly, a relatively high number of cyclin D1-positive cells (i.e., >10%) was also found in all cases of Spitz nevus [7].

Gene context of Nevus, Epithelioid and Spindle Cell

Proliferative activity in Spitz nevus (SN) was determined using proliferating cell nuclear antigen (PCNA) immunostaining and by assessing the mitotic rate [8].
As many as 76% of the Spitz nevus cases showed a low percentage (0-2%) of MIB-1 immunoreactivity [9].
BACKGROUND: Congenital Spitz nevus has been reported previously in the literature, but the histopathologic features have not been examined in detail [2].
Immunohistochemical study of p53 protein expression in Spitz nevus as compared with other melanocytic lesions [10].
A firm, dark reddish, smooth surfaced nodule on the forearm of a 16-year-old boy was diagnosed as a Spitz nevus with the aid of a strong positive reactivity to S-100 protein [11].

References

Use of Bayes rule and MIB-1 proliferation index to discriminate Spitz nevus from malignant melanoma. Vollmer, R.T. Am. J. Clin. Pathol. (2004) [Pubmed]
Congenital spitz nevus. Harris, M.N., Hurwitz, R.M., Buckel, L.J., Gray, H.R. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2000) [Pubmed]
High-resolution array-based comparative genomic hybridization for distinguishing paraffin-embedded Spitz nevi and melanomas. Harvell, J.D., Kohler, S., Zhu, S., Hernandez-Boussard, T., Pollack, J.R., van de Rijn, M. Diagn. Mol. Pathol. (2004) [Pubmed]
Expression of proliferating cell nuclear antigen in Spitz nevus. Penneys, N., Seigfried, E., Nahass, G., Vogler, C. J. Am. Acad. Dermatol. (1995) [Pubmed]
Expression of c-kit (CD117) in Spitz nevus and malignant melanoma. Isabel Zhu, Y., Fitzpatrick, J.E. J. Cutan. Pathol. (2006) [Pubmed]
Myxoid Spitz nevus. Hoang, M.P. J. Cutan. Pathol. (2003) [Pubmed]
Cyclin D1 overexpression in Spitz nevi: an immunohistochemical study. Nagasaka, T., Lai, R., Medeiros, L.J., Brynes, R.K., McCourty, A., Harada, T., Saddik, M. The American Journal of dermatopathology. (1999) [Pubmed]
Proliferative activities in Spitz nevus compared with melanocytic nevus and malignant melanoma using expression of PCNA/cyclin and mitotic rate. Tu, P., Miyauchi, S., Miki, Y. The American Journal of dermatopathology. (1993) [Pubmed]
Immunohistochemical markers for distinguishing Spitz nevi from malignant melanomas. Kanter-Lewensohn, L., Hedblad, M.A., Wejde, J., Larsson, O. Mod. Pathol. (1997) [Pubmed]
Immunohistochemical study of p53 protein expression in Spitz nevus as compared with other melanocytic lesions. Bergman, R., Shemer, A., Levy, R., Friedman-Birnbaum, R., Trau, H., Lichtig, C. The American Journal of dermatopathology. (1995) [Pubmed]
Intradermal Spitz nevus differentiated from reticulohistiocytic granuloma by immunoreactivity to S-100 protein. Kato, N., Ueno, H. J. Dermatol. (1990) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.