Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MIB1 - mindbomb E3 ubiquitin protein ligase 1

Homo sapiens

Synonyms: DAPK-interacting protein 1, DIP-1, DIP1, E3 ubiquitin-protein ligase MIB1, KIAA1323, ...

Henshall, D.C. et al., Berndt, J., Wang, Z. et al.

Jason Berndt,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Note that Ki-67 ( Entrez geneID:4288) is not the same as mindbomb homolog 1 (MIB1, aka DIP-1, Entrez geneID:57534)

Disease relevance of MIB1

Psychiatry related information on MIB1

High impact information on MIB1

Chemical compound and disease context of MIB1

Biological context of MIB1

Anatomical context of MIB1

Associations of MIB1 with chemical compounds

Physical interactions of MIB1

DAP kinase and DAP kinase-interacting protein 1 (DIP-1) localized to mitochondria in control brain, whereas levels of both were increased in the cytoplasm and microsomal (endoplasmic reticulum) fraction in epilepsy samples [1].

Regulatory relationships of MIB1

Finally, immunohistochemistry determined DAP kinase was coexpressed with DIP-1 in neurons [1].

Other interactions of MIB1

Thus, DOC-2/DAB2 and DIP1/2 appear to represent a unique negative regulatory complex that maintains cell homeostasis [2].

Analytical, diagnostic and therapeutic context of MIB1

References

Death-associated protein kinase expression in human temporal lobe epilepsy. Henshall, D.C., Schindler, C.K., So, N.K., Lan, J.Q., Meller, R., Simon, R.P. Ann. Neurol. (2004) [Pubmed]
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. Wang, Z., Tseng, C.P., Pong, R.C., Chen, H., McConnell, J.D., Navone, N., Hsieh, J.T. J. Biol. Chem. (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP011932	Anopheles gambiae str. PEST
MIB1	Bos taurus
MIB1	Canis lupus familiaris
mib1	Danio rerio
mib1	Drosophila melanogaster
MIB1	Gallus gallus
MIB1	Macaca mulatta
Mib1	Mus musculus
MIB1	Pan troglodytes
Mib1	Rattus norvegicus
mib1	Xenopus (Silurana) tropicalis

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