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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Potyviridae

  • A survey of gene sequences of species of Potyviridae, the most numerous family of plant viruses, has shown that the -GNNS- encoding region of the NIb gene is present in all c. 300 publicly available sequences of that region [1].

High impact information on Potyviridae

  • Collectively, these results indicate that HC-Pro from distantly related virus species of the family Potyviridae are competent to provide WSMV-Sidney 81 with all functions necessary for infection of a permissive host (wheat) and that virus-host interactions required for systemic infection of oat and SDp2 corn are more stringent [2].
  • Monopartite members of the family Potyviridae utilize three virus-encoded proteinases to cleave the viral polyprotein into mature proteins [3].
  • AgMV (9540 nucleotides) and HoMV (9463 nucleotides) each encode a single polyprotein with proteinase cleavage sites demarcating protein products characteristic of monopartite species of the family Potyviridae [4].
  • The RNA of CVYV encodes a single polyprotein of 3148 amino acid residues and has a deduced genome organization and motifs typical for a member of the family Potyviridae [5].
  • Two putative polyprotein cleavage sites were found: Q/L and E/A, both of which are novel in the Potyviridae [6].

Gene context of Potyviridae

  • The sequence is consistent with the NIb and coat protein regions of a member of the Potyviridae family of viruses [7].


  1. The 'potyvirid primers' will probably provide phylogenetically informative DNA fragments from all species of Potyviridae. Gibbs, A.J., Mackenzie, A.M., Gibbs, M.J. J. Virol. Methods (2003) [Pubmed]
  2. Functional replacement of Wheat streak mosaic virus HC-Pro with the corresponding cistron from a diverse array of viruses in the family Potyviridae. Stenger, D.C., French, R. Virology (2004) [Pubmed]
  3. Mapping of the P1 proteinase cleavage site in the polyprotein of Wheat streak mosaic virus (genus Tritimovirus). Choi, I.R., Horken, K.M., Stenger, D.C., French, R. J. Gen. Virol. (2002) [Pubmed]
  4. Genome sequences of Agropyron mosaic virus and Hordeum mosaic virus support reciprocal monophyly of the genera Potyvirus and Rymovirus in the family Potyviridae. French, R., Stenger, D.C. Arch. Virol. (2005) [Pubmed]
  5. Absence of a coding region for the helper component-proteinase in the genome of cucumber vein yellowing virus, a whitefly-transmitted member of the Potyviridae. Janssen, D., Martín, G., Velasco, L., Gómez, P., Segundo, E., Ruiz, L., Cuadrado, I.M. Arch. Virol. (2005) [Pubmed]
  6. Molecular cloning and nucleotide sequencing of the 3'-terminal region of a South African isolate of ryegrass mosaic virus RNA and in vitro expression of the coat protein gene. Salm, S.N., Rey, M.E., French, R. Arch. Virol. (1996) [Pubmed]
  7. Molecular evidence that the aphid-transmitted Tomato mild mottle virus belongs to the Potyviridae family but not the Potyvirus genus. Monger, W.A., Spence, N.J., Foster, G.D. Arch. Virol. (2001) [Pubmed]
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