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Gene Review

WSMVgp1  -  polyprotein

Wheat streak mosaic virus

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Disease relevance of WSMVgp1

  • Mapping of the P1 proteinase cleavage site in the polyprotein of Wheat streak mosaic virus (genus Tritimovirus) [1].
  • Monopartite members of the family Potyviridae utilize three virus-encoded proteinases to cleave the viral polyprotein into mature proteins [1].
  • An alignment of potyvirus polyprotein sequences in the carboxy-terminal region of the P1 domain revealed WSMV P1 contained conserved H(257), D(267), S(303) and FIVXG(325-329) residues upstream of the cleavage site that are typical of serine proteinases and shown by others to be required for P1 proteolysis in Tobacco etch virus [1].

High impact information on WSMVgp1

  • Inserts bearing the coding sequences of NPT II and beta-glucuronidase (GUS) were placed between the nuclear inclusion b (NIb) and coat protein (CP) domains of the wheat streak mosaic virus (WSMV) polyprotein ORF [2].
  • The WSMV NIb-CP junction containing the nuclear inclusion a (NIa) protease cleavage site was duplicated, permitting excision of foreign protein domains from the viral polyprotein [2].
  • Because the pathway of proteolytic maturation of the WSMV polyprotein has not been experimentally determined, random libraries of WSMV cDNA were made both in DNA-binding domain and activation domain plasmid vectors and introduced into yeast [3].
  • A comparison of this sequence along with the 3' terminal 1315 nucleotides of SCSMV-AP determined earlier with the other members of the family Potyviridae indicated that it had only 30% identity at the amino acid level for the partial polyprotein open reading frame (ORF) with the members of Ipomovirus and Tritimovirus genera [4].


  1. Mapping of the P1 proteinase cleavage site in the polyprotein of Wheat streak mosaic virus (genus Tritimovirus). Choi, I.R., Horken, K.M., Stenger, D.C., French, R. J. Gen. Virol. (2002) [Pubmed]
  2. A plant virus vector for systemic expression of foreign genes in cereals. Choi, I.R., Stenger, D.C., Morris, T.J., French, R. Plant J. (2000) [Pubmed]
  3. Multiple interactions among proteins encoded by the mite-transmitted wheat streak mosaic tritimovirus. Choi, I.R., Stenger, D.C., French, R. Virology (2000) [Pubmed]
  4. Taxonomic position of sugarcane streak mosaic virus in the family Potyviridae. Hema, M., Sreenivasulu, P., Savithri, H.S. Arch. Virol. (2002) [Pubmed]
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