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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MeSH Review: 

Drug Resistance, Fungal

 
 
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High impact information on Drug Resistance, Fungal

  • A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance [1].
  • These studies demonstrate that the activity of non-azole antifungal agents that target ergosterol biosynthesis can be enhanced by inhibition of the calcineurin signaling pathway, extending their spectrum of action and providing an alternative approach by which to overcome antifungal drug resistance [2].

References

  1. A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. de Micheli, M., Bille, J., Schueller, C., Sanglard, D. Mol. Microbiol. (2002) [Pubmed]
  2. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Onyewu, C., Blankenship, J.R., Del Poeta, M., Heitman, J. Antimicrob. Agents Chemother. (2003) [Pubmed]
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