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MeSH Review:

Enzyme Repression

Yoshiga, K. et al., Crabeel, M. et al., Olson, E.N. et al., Borgia, P. et al., Goodman, I. et al., et al.

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Disease relevance of Enzyme Repression

Accumulation of arginine precursors in Escherichia coli: effects on growth, enzyme repression, and application to the forward selection of arginine auxotrophs [1].

High impact information on Enzyme Repression

These results rule out enzyme repression as a major factor in controlling arginine biosynthesis [2].
Under conditions of enzyme repression, however, the newly synthesized creatine phosphokinase appears to be enzymatically inactive [3].
The results show that NAPRTase is subject only to a modest degree of enzyme repression [4].
In addition, exogenous cyclic adenosine 3',5'-monophosphate (cAMP) resulted in enzyme repression [5].
Furthermore, based on the results of an experiment performed with animals that had been treated with a metabolic inhibitor, azacholesterol, it is suggested that the disappearance of these sterols may be due to enzyme repression instead of increased activity of the pathway [6].

References

Accumulation of arginine precursors in Escherichia coli: effects on growth, enzyme repression, and application to the forward selection of arginine auxotrophs. Crabeel, M., Charlier, D., Cunin, R., Boyen, A., Glansdorff, N., Piérard, A. J. Bacteriol. (1975) [Pubmed]
Control of arginine metabolism in Neurospora crassa. Role of feedback inhibition. Goodman, I., Weiss, R.L. J. Biol. Chem. (1986) [Pubmed]
Regulation of creatine phosphokinase expression during differentiation of BC3H1 cells. Olson, E.N., Caldwell, K.L., Gordon, J.I., Glaser, L. J. Biol. Chem. (1983) [Pubmed]
Periplasmic localization of nicotinate phosphoribosyltransferase in Escherichia coli. Baecker, P.A., Yung, S.G., Rodriguez, M., Austin, E., Andreoli, A.J. J. Bacteriol. (1978) [Pubmed]
Control of beta-glucosidase synthesis in Mucor racemosus. Borgia, P., Sypherd, P.S. J. Bacteriol. (1977) [Pubmed]
Changes of sterol metabolism during 3-methylcholanthrene-induced mouse skin carcinogenesis. Yoshiga, K., Hayashi, T., Takada, K., Okuda, K. Gann = Gan. (1981) [Pubmed]

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