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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MeSH Review: 

Nucleic Acid Conformation

 
 
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High impact information on Nucleic Acid Conformation

  • Bleomycin (BLM) binding and chemistry are apparently sensitive to differences in nucleic acid conformation and could conceivably be developed as a probe for sequence-dependent elements of conformation [1].
  • BBR3464 binding to different nucleic acid conformations raises the possibility that the adducts of single-stranded DNA and RNA may play a role in the different antitumor efficacies of this novel drug as compared with cisplatin [2].
  • The results obtained demonstrate that the formation of a covalently bound adduct in which anthramycin is attached to the N2 site of a guanine within a DNA fragment is accompanied by a considerable change in the nucleic acid conformation as confirmed by recent experimental evidence [3].
  • In order to study the dynamics of protein and nucleic acid conformations, a molecular folding-unfolding system (FUS written in Lisp) has been developed [4].

References

  1. Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers. Bansal, M., Lee, J.S., Stubbe, J., Kozarich, J.W. Nucleic Acids Res. (1997) [Pubmed]
  2. Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug. Kloster, M.B., Hannis, J.C., Muddiman, D.C., Farrell, N. Biochemistry (1999) [Pubmed]
  3. A theoretical investigation of the sequence specificity in the binding of the antitumor drug anthramycin to DNA. Zakrzewska, K., Pullman, B. J. Biomol. Struct. Dyn. (1986) [Pubmed]
  4. FUS: a system to simulate conformational changes in biological macromolecules. Major, F., Feldmann, R., Lapalme, G., Cedergren, R. Comput. Appl. Biosci. (1988) [Pubmed]
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