The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nucleic Acid Conformation

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Nucleic Acid Conformation

  • Bleomycin (BLM) binding and chemistry are apparently sensitive to differences in nucleic acid conformation and could conceivably be developed as a probe for sequence-dependent elements of conformation [1].
  • BBR3464 binding to different nucleic acid conformations raises the possibility that the adducts of single-stranded DNA and RNA may play a role in the different antitumor efficacies of this novel drug as compared with cisplatin [2].
  • The results obtained demonstrate that the formation of a covalently bound adduct in which anthramycin is attached to the N2 site of a guanine within a DNA fragment is accompanied by a considerable change in the nucleic acid conformation as confirmed by recent experimental evidence [3].
  • In order to study the dynamics of protein and nucleic acid conformations, a molecular folding-unfolding system (FUS written in Lisp) has been developed [4].


  1. Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers. Bansal, M., Lee, J.S., Stubbe, J., Kozarich, J.W. Nucleic Acids Res. (1997) [Pubmed]
  2. Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug. Kloster, M.B., Hannis, J.C., Muddiman, D.C., Farrell, N. Biochemistry (1999) [Pubmed]
  3. A theoretical investigation of the sequence specificity in the binding of the antitumor drug anthramycin to DNA. Zakrzewska, K., Pullman, B. J. Biomol. Struct. Dyn. (1986) [Pubmed]
  4. FUS: a system to simulate conformational changes in biological macromolecules. Major, F., Feldmann, R., Lapalme, G., Cedergren, R. Comput. Appl. Biosci. (1988) [Pubmed]
WikiGenes - Universities