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High impact information on Tussilago

  • L-652,469, 14-acetoxy-7 beta-(3'-ethylcrotonoyloxy)-notonipetranone, isolated from the methylene chloride extracts of the buds of Tussilago farfara L, was found to inhibit both platelet activating factor (PAF) and Ca2+ entry blocker binding to membrane vesicles [1].
  • A new bisabolene epoxide was isolated from the flower buds of Tussilago farfara, and the structure was determined by spectroscopic methods to be 1alpha,5alpha-bisacetoxy-8-angeloyloxy-3beta, 4beta-epoxy-bisabola-7(14),10-dien-2-one (1) [2].
  • Neuroprotective and antioxidant effects of the ethyl acetate fraction prepared from Tussilago farfara L [3].
  • Chemical studies on the dried, young flowers used in this experiment suggested that the carcinogenicity of coltsfoot is most probably due to senkirkine, a hepatotoxic pyrrolizidine alkaloid [4].


  1. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Hwang, S.B., Chang, M.N., Garcia, M.L., Han, Q.Q., Huang, L., King, V.F., Kaczorowski, G.J., Winquist, R.J. Eur. J. Pharmacol. (1987) [Pubmed]
  2. A new bisabolene epoxide from Tussilago farfara, and inhibition of nitric oxide synthesis in LPS-activated macrophages. Ryu, J.H., Jeong, Y.S., Sohn, D.H. J. Nat. Prod. (1999) [Pubmed]
  3. Neuroprotective and antioxidant effects of the ethyl acetate fraction prepared from Tussilago farfara L. Cho, J., Kim, H.M., Ryu, J.H., Jeong, Y.S., Lee, Y.S., Jin, C. Biol. Pharm. Bull. (2005) [Pubmed]
  4. Carcinogenic activity of coltsfoot, Tussilago farfara l. Hirono, I., Mori, H., Culvenor, C.C. Gann = Gan. (1976) [Pubmed]
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